Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309410471> ?p ?o ?g. }
- W4309410471 endingPage "6406" @default.
- W4309410471 startingPage "6401" @default.
- W4309410471 abstract "The synthesis of high-value-added C1-deuterated aldehydes would improve the availability of deuterated lead compounds for deuterium-labeled drug discovery. Herein, we develop a metal-free synthesis of C1-deuterated aldehydes with D2O from α-oxo carboxylic acids at ambient temperature. Via visible-light photoredox-catalyzed decarboxylation, stoichiometric reductants and oxidants were avoided. Various functional groups were tolerated and resulted in C1-deuterium aldehydes in up to 92% yield and 91–97% D incorporation under mild conditions. This method is also applied to the synthesis of various aldehydes. Primary mechanistic studies indicate that the catalytic pathway occurs via a reductive quenching pathway followed by hydrogen atom transfer." @default.
- W4309410471 created "2022-11-27" @default.
- W4309410471 creator A5012492614 @default.
- W4309410471 creator A5014927466 @default.
- W4309410471 date "2022-11-18" @default.
- W4309410471 modified "2023-10-16" @default.
- W4309410471 title "Visible-Light Photoredox-Catalyzed Decarboxylation of α-Oxo Carboxylic Acids to C1-Deuterated Aldehydes and Aldehydes" @default.
- W4309410471 cites W1969899354 @default.
- W4309410471 cites W1972556138 @default.
- W4309410471 cites W1977017618 @default.
- W4309410471 cites W1979259658 @default.
- W4309410471 cites W2036359894 @default.
- W4309410471 cites W2062434355 @default.
- W4309410471 cites W2063566653 @default.
- W4309410471 cites W2065599241 @default.
- W4309410471 cites W2069887352 @default.
- W4309410471 cites W2071982166 @default.
- W4309410471 cites W2088699227 @default.
- W4309410471 cites W2101439709 @default.
- W4309410471 cites W2110458223 @default.
- W4309410471 cites W2112816631 @default.
- W4309410471 cites W2319505350 @default.
- W4309410471 cites W2339932420 @default.
- W4309410471 cites W2483112172 @default.
- W4309410471 cites W2614565143 @default.
- W4309410471 cites W2622138635 @default.
- W4309410471 cites W2746123056 @default.
- W4309410471 cites W2748499193 @default.
- W4309410471 cites W2767689204 @default.
- W4309410471 cites W2794158253 @default.
- W4309410471 cites W2883599686 @default.
- W4309410471 cites W2896664526 @default.
- W4309410471 cites W2938213779 @default.
- W4309410471 cites W2969617483 @default.
- W4309410471 cites W2973191462 @default.
- W4309410471 cites W2981761949 @default.
- W4309410471 cites W2992501567 @default.
- W4309410471 cites W3001619876 @default.
- W4309410471 cites W3010575255 @default.
- W4309410471 cites W3047385792 @default.
- W4309410471 cites W3073520559 @default.
- W4309410471 cites W3107347394 @default.
- W4309410471 cites W3120897700 @default.
- W4309410471 cites W3170313048 @default.
- W4309410471 cites W3190240776 @default.
- W4309410471 cites W3207963052 @default.
- W4309410471 cites W3213603211 @default.
- W4309410471 cites W4206001041 @default.
- W4309410471 cites W4211250191 @default.
- W4309410471 cites W4221124513 @default.
- W4309410471 cites W4226173123 @default.
- W4309410471 cites W4229374399 @default.
- W4309410471 cites W4285731995 @default.
- W4309410471 cites W4288038891 @default.
- W4309410471 cites W4292813825 @default.
- W4309410471 cites W4296492611 @default.
- W4309410471 cites W52280030 @default.
- W4309410471 doi "https://doi.org/10.1021/acs.joc.2c02299" @default.
- W4309410471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36399788" @default.
- W4309410471 hasPublicationYear "2022" @default.
- W4309410471 type Work @default.
- W4309410471 citedByCount "4" @default.
- W4309410471 countsByYear W43094104712023 @default.
- W4309410471 crossrefType "journal-article" @default.
- W4309410471 hasAuthorship W4309410471A5012492614 @default.
- W4309410471 hasAuthorship W4309410471A5014927466 @default.
- W4309410471 hasConcept C121332964 @default.
- W4309410471 hasConcept C121745418 @default.
- W4309410471 hasConcept C134121241 @default.
- W4309410471 hasConcept C161790260 @default.
- W4309410471 hasConcept C178790620 @default.
- W4309410471 hasConcept C185592680 @default.
- W4309410471 hasConcept C191897082 @default.
- W4309410471 hasConcept C192562407 @default.
- W4309410471 hasConcept C2779074116 @default.
- W4309410471 hasConcept C2779825165 @default.
- W4309410471 hasConcept C2780595602 @default.
- W4309410471 hasConcept C58364064 @default.
- W4309410471 hasConcept C62520636 @default.
- W4309410471 hasConcept C75473681 @default.
- W4309410471 hasConcept C91881484 @default.
- W4309410471 hasConceptScore W4309410471C121332964 @default.
- W4309410471 hasConceptScore W4309410471C121745418 @default.
- W4309410471 hasConceptScore W4309410471C134121241 @default.
- W4309410471 hasConceptScore W4309410471C161790260 @default.
- W4309410471 hasConceptScore W4309410471C178790620 @default.
- W4309410471 hasConceptScore W4309410471C185592680 @default.
- W4309410471 hasConceptScore W4309410471C191897082 @default.
- W4309410471 hasConceptScore W4309410471C192562407 @default.
- W4309410471 hasConceptScore W4309410471C2779074116 @default.
- W4309410471 hasConceptScore W4309410471C2779825165 @default.
- W4309410471 hasConceptScore W4309410471C2780595602 @default.
- W4309410471 hasConceptScore W4309410471C58364064 @default.
- W4309410471 hasConceptScore W4309410471C62520636 @default.
- W4309410471 hasConceptScore W4309410471C75473681 @default.
- W4309410471 hasConceptScore W4309410471C91881484 @default.
- W4309410471 hasFunder F4320321001 @default.
- W4309410471 hasFunder F4320329878 @default.