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- W4309411870 abstract "Aging refers to a progressive decrease in functional performance, leading to increased mortality risk. At present, life expectancy is increasing worldwide and is expected to exceed 80 years by 2040. However, this increase in life expectancy also indicates a rise in the incidence and prevalence of diseases, such as cardiovascular, neurological, musculoskeletal, and oncological diseases, which are associated with aging. The exact underlying mechanisms of aging remain unknown, and whether it is a programmed process or the consequence of an accumulation of stress events remains unclear. Thus, more scientific research is needed to improve the management of complex and frail patients.Several databases were searched with the following key words: immunosenescence, inflamm-aging, frailty, sarcopenia and skeletal muscle, etc.Skeletal muscle is the core phenotype of frailty and sarcopenia. Immune aging and skeletal muscle decline interplay with each other and form a vicious circle. Maintaining muscle health is beneficial for immune function and delays the onset of frailty. Particularly, in the context of the ongoing corona virus disease (COVID)-19 pandemic, studies have shown that the elderly are more prone to the consequences of the SARS-CoV-2 virus. It has been reported that the rates of hospitalization in the 65-74, 75-84, and ≥85 years old group were 5×, 8×, and 10× greater than the 18-29 years old group, with corresponding COVID-19-related deaths being 60×, 140×, and 330× that of the younger reference group, respectively. Considering the above, this review aims to discuss the relationship between immunosenescence, skeletal muscle, and frailty, and to explore immunosenescence as a potential therapeutic target to prevent frailty and extend healthspan, with some emphasis on the effects of the COVID-19 pandemic on the elderly.Immunosenescence is a promising potential therapeutic target for frailty and is worthy of further investigation." @default.
- W4309411870 created "2022-11-27" @default.
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- W4309411870 date "2022-10-01" @default.
- W4309411870 modified "2023-10-01" @default.
- W4309411870 title "Immunosenescence is a therapeutic target for frailty in older adults: a narrative review" @default.
- W4309411870 cites W103399905 @default.
- W4309411870 cites W1481432786 @default.
- W4309411870 cites W1504906459 @default.
- W4309411870 cites W1580812738 @default.
- W4309411870 cites W1604514465 @default.
- W4309411870 cites W1981904722 @default.
- W4309411870 cites W1996398553 @default.
- W4309411870 cites W1996454121 @default.
- W4309411870 cites W2020931454 @default.
- W4309411870 cites W2028805513 @default.
- W4309411870 cites W2038120788 @default.
- W4309411870 cites W2047457444 @default.
- W4309411870 cites W2048353385 @default.
- W4309411870 cites W2050870518 @default.
- W4309411870 cites W2063192133 @default.
- W4309411870 cites W2070779815 @default.
- W4309411870 cites W2071843907 @default.
- W4309411870 cites W2074160143 @default.
- W4309411870 cites W2092170177 @default.
- W4309411870 cites W2111074957 @default.
- W4309411870 cites W2120072658 @default.
- W4309411870 cites W2139520621 @default.
- W4309411870 cites W2142514031 @default.
- W4309411870 cites W2151328705 @default.
- W4309411870 cites W2156305960 @default.
- W4309411870 cites W2159914115 @default.
- W4309411870 cites W2164059021 @default.
- W4309411870 cites W2190816033 @default.
- W4309411870 cites W2316395586 @default.
- W4309411870 cites W2336066775 @default.
- W4309411870 cites W2400762424 @default.
- W4309411870 cites W2466333719 @default.
- W4309411870 cites W2531162495 @default.
- W4309411870 cites W2555114181 @default.
- W4309411870 cites W2560367415 @default.
- W4309411870 cites W2572010293 @default.
- W4309411870 cites W2572174216 @default.
- W4309411870 cites W2623238236 @default.
- W4309411870 cites W2735863008 @default.
- W4309411870 cites W2736299453 @default.
- W4309411870 cites W2738967877 @default.
- W4309411870 cites W2761110089 @default.
- W4309411870 cites W2765227396 @default.
- W4309411870 cites W2790205792 @default.
- W4309411870 cites W2796661030 @default.
- W4309411870 cites W2860743873 @default.
- W4309411870 cites W2888722873 @default.
- W4309411870 cites W2897257410 @default.
- W4309411870 cites W2897513125 @default.
- W4309411870 cites W2898657559 @default.
- W4309411870 cites W2912567439 @default.
- W4309411870 cites W2930386701 @default.
- W4309411870 cites W2981890331 @default.
- W4309411870 cites W3000319248 @default.
- W4309411870 cites W3006183612 @default.
- W4309411870 cites W3011610993 @default.
- W4309411870 cites W3011669642 @default.
- W4309411870 cites W3013981081 @default.
- W4309411870 cites W3035168996 @default.
- W4309411870 cites W3046449061 @default.
- W4309411870 cites W3084879098 @default.
- W4309411870 cites W3088962076 @default.
- W4309411870 cites W3089880422 @default.
- W4309411870 cites W3109777881 @default.
- W4309411870 cites W3115773653 @default.
- W4309411870 cites W3119454797 @default.
- W4309411870 cites W3120873513 @default.
- W4309411870 cites W3123199686 @default.
- W4309411870 cites W3135032275 @default.
- W4309411870 cites W3153162508 @default.
- W4309411870 cites W3161778279 @default.
- W4309411870 cites W3168527459 @default.
- W4309411870 cites W3171336969 @default.
- W4309411870 cites W3172838821 @default.
- W4309411870 cites W3178657798 @default.
- W4309411870 cites W3192644687 @default.
- W4309411870 cites W3194316549 @default.
- W4309411870 cites W3196392682 @default.
- W4309411870 cites W3200259362 @default.
- W4309411870 cites W3209376120 @default.
- W4309411870 cites W4207063552 @default.
- W4309411870 cites W4223472707 @default.
- W4309411870 doi "https://doi.org/10.21037/atm-22-4405" @default.
- W4309411870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36388790" @default.
- W4309411870 hasPublicationYear "2022" @default.