Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309436620> ?p ?o ?g. }
- W4309436620 abstract "There are hundreds of central nervous system (CNS) diseases, but there are few diseases for which the etiology or pathogenesis is understood as well as those of other organ-specific diseases. Cells in the CNS are selectively protected from external and internal insults by the blood-brain barrier. Thus, the neuroimmune system, including microglia and immune proteins, might control external or internal insults that the adaptive immune system cannot control or mitigate. The pathologic findings differ by disease and show a state of inflammation that reflects the relationship between etiological or inflammation-inducing substances and corresponding immune reactions. Current immunological concepts about infectious diseases and infection-associated immune-mediated diseases, including those in the CNS, can only partly explain the pathophysiology of disease because they are based on the idea that host cell injury is caused by pathogens. Because every disease involves etiological or triggering substances for disease-onset, the protein-homeostasis-system (PHS) hypothesis proposes that the immune systems in the host control those substances according to the size and biochemical properties of the substances. In this article, I propose a common immunopathogenesis of CNS diseases, including prion diseases, Alzheimer's disease, and genetic diseases, through the PHS hypothesis." @default.
- W4309436620 created "2022-11-27" @default.
- W4309436620 creator A5056018098 @default.
- W4309436620 date "2022-11-16" @default.
- W4309436620 modified "2023-09-30" @default.
- W4309436620 title "Common immunopathogenesis of central nervous system diseases: the protein-homeostasis-system hypothesis" @default.
- W4309436620 cites W1515023627 @default.
- W4309436620 cites W1527289043 @default.
- W4309436620 cites W1544064013 @default.
- W4309436620 cites W1594747697 @default.
- W4309436620 cites W1927911758 @default.
- W4309436620 cites W1964004941 @default.
- W4309436620 cites W1972351022 @default.
- W4309436620 cites W1975275391 @default.
- W4309436620 cites W1978697586 @default.
- W4309436620 cites W1979285653 @default.
- W4309436620 cites W1983836633 @default.
- W4309436620 cites W1984415303 @default.
- W4309436620 cites W1990999761 @default.
- W4309436620 cites W1999477136 @default.
- W4309436620 cites W2000903854 @default.
- W4309436620 cites W2014766007 @default.
- W4309436620 cites W2017484438 @default.
- W4309436620 cites W2019288170 @default.
- W4309436620 cites W2031978571 @default.
- W4309436620 cites W2042851093 @default.
- W4309436620 cites W2042978244 @default.
- W4309436620 cites W2046445620 @default.
- W4309436620 cites W2055499091 @default.
- W4309436620 cites W2070498846 @default.
- W4309436620 cites W2073654219 @default.
- W4309436620 cites W2090844619 @default.
- W4309436620 cites W2095851810 @default.
- W4309436620 cites W2098038342 @default.
- W4309436620 cites W2110420813 @default.
- W4309436620 cites W2111583447 @default.
- W4309436620 cites W2116797415 @default.
- W4309436620 cites W2123097904 @default.
- W4309436620 cites W2124334590 @default.
- W4309436620 cites W2138498069 @default.
- W4309436620 cites W2140703071 @default.
- W4309436620 cites W2142596090 @default.
- W4309436620 cites W2143411464 @default.
- W4309436620 cites W2145736817 @default.
- W4309436620 cites W2165334692 @default.
- W4309436620 cites W2198497392 @default.
- W4309436620 cites W2233660390 @default.
- W4309436620 cites W2280783985 @default.
- W4309436620 cites W2327641970 @default.
- W4309436620 cites W2343758687 @default.
- W4309436620 cites W2467200611 @default.
- W4309436620 cites W2523849022 @default.
- W4309436620 cites W2550855113 @default.
- W4309436620 cites W2556426925 @default.
- W4309436620 cites W2570634615 @default.
- W4309436620 cites W2572551054 @default.
- W4309436620 cites W2577163397 @default.
- W4309436620 cites W2613018513 @default.
- W4309436620 cites W2668588294 @default.
- W4309436620 cites W2744715029 @default.
- W4309436620 cites W2756587894 @default.
- W4309436620 cites W2763305669 @default.
- W4309436620 cites W2763748630 @default.
- W4309436620 cites W2773404756 @default.
- W4309436620 cites W2789917838 @default.
- W4309436620 cites W2798115114 @default.
- W4309436620 cites W2888160268 @default.
- W4309436620 cites W2920009718 @default.
- W4309436620 cites W2920155422 @default.
- W4309436620 cites W2932093126 @default.
- W4309436620 cites W2944097389 @default.
- W4309436620 cites W2945318241 @default.
- W4309436620 cites W2946156712 @default.
- W4309436620 cites W2966046000 @default.
- W4309436620 cites W2986976548 @default.
- W4309436620 cites W2994917266 @default.
- W4309436620 cites W2996152507 @default.
- W4309436620 cites W3004544639 @default.
- W4309436620 cites W3005382457 @default.
- W4309436620 cites W3009920944 @default.
- W4309436620 cites W3016096986 @default.
- W4309436620 cites W3022029286 @default.
- W4309436620 cites W3029724486 @default.
- W4309436620 cites W3035914962 @default.
- W4309436620 cites W3036166911 @default.
- W4309436620 cites W3036301913 @default.
- W4309436620 cites W3042629065 @default.
- W4309436620 cites W3044752815 @default.
- W4309436620 cites W3067716055 @default.
- W4309436620 cites W3068647859 @default.
- W4309436620 cites W3080211491 @default.
- W4309436620 cites W3081228941 @default.
- W4309436620 cites W3097395965 @default.
- W4309436620 cites W3104682194 @default.
- W4309436620 cites W3109691907 @default.
- W4309436620 cites W3116025084 @default.
- W4309436620 cites W3120213857 @default.
- W4309436620 cites W3122128474 @default.
- W4309436620 cites W3123214671 @default.
- W4309436620 cites W3126654127 @default.