FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309448168> ?p ?o ?g. }

• W4309448168 endingPage "115167" @default.
• W4309448168 startingPage "115167" @default.
• W4309448168 abstract "Ampicillin in combination with sulbactam is a widely used drug choice for infection prophylaxis, especially in oral and maxillofacial surgery. Clindamycin serves as an alternative in patients with known allergy to β-lactam antibiotics. To ensure effective prophylaxis, it is important to achieve sufficiently high concentrations of active antibiotic substances in the tissues affected by the surgery. To this end, a LC-MS/MS method was developed and validated that allows the quantification of ampicillin, sulbactam and clindamycin in jawbone, plasma, and so-called platelet-rich fibrin (PRF). Validation was performed in accordance with the European Medicines Agency guidelines for bioanalytical method validation. For all matrices, sample processing was carried out by protein precipitation with acetonitrile or methanol 80%, containing the isotope labelled internal standards (IS) of the three drugs. Analytes were separated on a pentaflourophenyl column at 20 °C using gradient elution. Furthermore, detection was accomplished by electrospray ionisation in positive-ion mode (ampicillin, clindamycin and corresponding IS) and negative-ion mode (sulbactam and corresponding IS) in combination with multiple reaction monitoring. Depending on the analyte and the matrix under investigation, calibration curves ranged from 0.14 to 59.8 µg/g (jawbone - ampicillin), 2.0-1000 µg/mL (plasma - ampicillin), and 1.0-495 µg/mL (PRF - ampicillin). All analytes fulfilled the requirements of the guideline regarding sensitivity, linearity, selectivity, carryover, within-run and between run accuracy and precision, matrix effect and extraction recovery in all matrices. The method was successfully applied to measure concentrations of ampicillin, sulbactam and clindamycin in real-life samples obtained in routine clinical practice." @default.
• W4309448168 created "2022-11-28" @default.
• W4309448168 creator A5010774833 @default.
• W4309448168 creator A5054723837 @default.
• W4309448168 creator A5057080440 @default.
• W4309448168 creator A5069833681 @default.
• W4309448168 creator A5070389278 @default.
• W4309448168 creator A5072839440 @default.
• W4309448168 date "2023-02-01" @default.
• W4309448168 modified "2023-09-26" @default.
• W4309448168 title "A liquid chromatography-tandem mass spectrometry method for the quantification of ampicillin/sulbactam and clindamycin in jawbone, plasma, and platelet-rich fibrin: Application to patients with osteonecrosis of the jaw" @default.
• W4309448168 cites W1555792281 @default.
• W4309448168 cites W1588750765 @default.
• W4309448168 cites W1969477911 @default.
• W4309448168 cites W1998344084 @default.
• W4309448168 cites W2001403426 @default.
• W4309448168 cites W2003786398 @default.
• W4309448168 cites W2049846605 @default.
• W4309448168 cites W2112475176 @default.
• W4309448168 cites W2113701549 @default.
• W4309448168 cites W2141858515 @default.
• W4309448168 cites W2145193397 @default.
• W4309448168 cites W2150760368 @default.
• W4309448168 cites W2153641174 @default.
• W4309448168 cites W2617852027 @default.
• W4309448168 cites W2754298368 @default.
• W4309448168 cites W2766305806 @default.
• W4309448168 cites W2771378988 @default.
• W4309448168 cites W2790962076 @default.
• W4309448168 cites W2799295634 @default.
• W4309448168 cites W2810262144 @default.
• W4309448168 cites W2889365262 @default.
• W4309448168 cites W2997433327 @default.
• W4309448168 cites W3011065076 @default.
• W4309448168 cites W3119391461 @default.
• W4309448168 cites W3194794611 @default.
• W4309448168 cites W39215153 @default.
• W4309448168 cites W4247877631 @default.
• W4309448168 cites W4295705246 @default.
• W4309448168 doi "https://doi.org/10.1016/j.jpba.2022.115167" @default.
• W4309448168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36435082" @default.
• W4309448168 hasPublicationYear "2023" @default.
• W4309448168 type Work @default.
• W4309448168 citedByCount "1" @default.
• W4309448168 countsByYear W43094481682023 @default.
• W4309448168 crossrefType "journal-article" @default.
• W4309448168 hasAuthorship W4309448168A5010774833 @default.
• W4309448168 hasAuthorship W4309448168A5054723837 @default.
• W4309448168 hasAuthorship W4309448168A5057080440 @default.
• W4309448168 hasAuthorship W4309448168A5069833681 @default.
• W4309448168 hasAuthorship W4309448168A5070389278 @default.
• W4309448168 hasAuthorship W4309448168A5072839440 @default.
• W4309448168 hasConcept C10390740 @default.
• W4309448168 hasConcept C162356407 @default.
• W4309448168 hasConcept C185592680 @default.
• W4309448168 hasConcept C2776021129 @default.
• W4309448168 hasConcept C2777458120 @default.
• W4309448168 hasConcept C2778478555 @default.
• W4309448168 hasConcept C2779631663 @default.
• W4309448168 hasConcept C31827203 @default.
• W4309448168 hasConcept C43617362 @default.
• W4309448168 hasConcept C501593827 @default.
• W4309448168 hasConcept C55493867 @default.
• W4309448168 hasConcept C71043704 @default.
• W4309448168 hasConcept C94665300 @default.
• W4309448168 hasConceptScore W4309448168C10390740 @default.
• W4309448168 hasConceptScore W4309448168C162356407 @default.
• W4309448168 hasConceptScore W4309448168C185592680 @default.
• W4309448168 hasConceptScore W4309448168C2776021129 @default.
• W4309448168 hasConceptScore W4309448168C2777458120 @default.
• W4309448168 hasConceptScore W4309448168C2778478555 @default.
• W4309448168 hasConceptScore W4309448168C2779631663 @default.
• W4309448168 hasConceptScore W4309448168C31827203 @default.
• W4309448168 hasConceptScore W4309448168C43617362 @default.
• W4309448168 hasConceptScore W4309448168C501593827 @default.
• W4309448168 hasConceptScore W4309448168C55493867 @default.
• W4309448168 hasConceptScore W4309448168C71043704 @default.
• W4309448168 hasConceptScore W4309448168C94665300 @default.
• W4309448168 hasLocation W43094481681 @default.
• W4309448168 hasLocation W43094481682 @default.
• W4309448168 hasOpenAccess W4309448168 @default.
• W4309448168 hasPrimaryLocation W43094481681 @default.
• W4309448168 hasRelatedWork W1989080374 @default.
• W4309448168 hasRelatedWork W1989896495 @default.
• W4309448168 hasRelatedWork W1998754189 @default.
• W4309448168 hasRelatedWork W2040912236 @default.
• W4309448168 hasRelatedWork W2046598237 @default.
• W4309448168 hasRelatedWork W2074280965 @default.
• W4309448168 hasRelatedWork W2080426285 @default.
• W4309448168 hasRelatedWork W2100932072 @default.
• W4309448168 hasRelatedWork W2169361849 @default.
• W4309448168 hasRelatedWork W2748990605 @default.
• W4309448168 hasVolume "224" @default.
• W4309448168 isParatext "false" @default.
• W4309448168 isRetracted "false" @default.
• W4309448168 workType "article" @default.