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- W4309452200 abstract "Sickle cell disease (SCD) is a collection of hemoglobinopathies that affects millions worldwide. 20 People with SCD are at high risk for neurocognitive complications, including stroke, silent cerebral 21 infarction, and slow processing speed. Strategies to mitigate risk are limited by an incomplete 22 understanding of the cerebral pathophysiology. Brain injury in SCD is believed to result from a 23 mismatch in the supply and demand for oxygen (Ford et al. 2018). Oxygen supply to the brain is 24 influenced by several factors, including hemoglobin concentration, arterial oxygen saturation, oxygen 25 affinity and dissociation from hemoglobin, oxygen delivery to the brain (the product of cerebral 26 blood flow (CBF) and arterial oxygen content (CaO2)), and oxygen extraction fraction (OEF; ratio of 27 oxygen consumed to oxygen delivered). While prior research has demonstrated that each of these 28 factors is abnormal in SCD, the degree and relationship between each covariate remains unclear. 29Therefore, the goal of this research topic is to present recent findings related to improving our 30 understanding of oxygen delivery and utilization in SCD. 31 CBF is a critical determinant of oxygen availability to the brain. Seminal works by (Herold et al. 32 1986) and (Prohovnik et al. 1989)" @default.
- W4309452200 created "2022-11-28" @default.
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- W4309452200 date "2022-11-21" @default.
- W4309452200 modified "2023-09-30" @default.
- W4309452200 title "Editorial: Cerebral oxygen supply and demand in sickle cell disease: Evidence of local ischemia despite global hyperemia" @default.
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- W4309452200 doi "https://doi.org/10.3389/fphys.2022.1079889" @default.
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