Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309452523> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4309452523 abstract "Background and Purpose Recent evidence suggests that postmenopausal osteoporosis is associated with increased bone resorption function in osteoclasts, of which Cathepsin K is a key molecule. In this study, we aimed to screen small molecule compounds targeting Cathepsin K and evaluate whether they affect osteoclast bone resorption function. Experimental Approach We screened out the small-molecule compound NVP-BHG712 targeting CTSK by molecular docking, and studied its pharmacological effect on bone resorption function of osteoclasts. To this end, we evaluated bone mass changes in postmenopausal mice by μCT, ELISA, and H&E staining. In addition, we also investigated the effects of NVP-BHG712 on osteoclast differentiation, bone resorption function and expression of osteoclast differentiation related factors in vitro. Key Results Surprisingly, we found that oral NVP-BHG712 treatment significantly reduced bone loss in postmenopausal mice. In vitro osteoclast culture, it was found that this effect was achieved by inhibiting osteoclast differentiation and bone resorption. Meanwhile, NVP-BHG712 significantly decreased the expression of genes related to osteoclast differentiation, including CTSK, MMP9, CTR, IP3R1, IP3R3, and OC-STAMP. Conclusion and Implications The present findings suggest that NVP-BHG712 reduces bone resorption function by inhibiting osteoclast differentiation, and is a potential drug for preventing and treating postmenopausal osteoporosis and other diseases." @default.
- W4309452523 created "2022-11-28" @default.
- W4309452523 creator A5000979147 @default.
- W4309452523 creator A5004654524 @default.
- W4309452523 creator A5004923438 @default.
- W4309452523 creator A5017947172 @default.
- W4309452523 creator A5021158772 @default.
- W4309452523 creator A5021384155 @default.
- W4309452523 creator A5021687717 @default.
- W4309452523 creator A5040695351 @default.
- W4309452523 creator A5051367687 @default.
- W4309452523 creator A5051886637 @default.
- W4309452523 creator A5056923910 @default.
- W4309452523 date "2022-11-21" @default.
- W4309452523 modified "2023-10-16" @default.
- W4309452523 title "NVP-BHG712 against postmenopausal osteoporosis in mice by targeting Cathepsin K" @default.
- W4309452523 doi "https://doi.org/10.22541/au.166902864.48107607/v1" @default.
- W4309452523 hasPublicationYear "2022" @default.
- W4309452523 type Work @default.
- W4309452523 citedByCount "0" @default.
- W4309452523 crossrefType "posted-content" @default.
- W4309452523 hasAuthorship W4309452523A5000979147 @default.
- W4309452523 hasAuthorship W4309452523A5004654524 @default.
- W4309452523 hasAuthorship W4309452523A5004923438 @default.
- W4309452523 hasAuthorship W4309452523A5017947172 @default.
- W4309452523 hasAuthorship W4309452523A5021158772 @default.
- W4309452523 hasAuthorship W4309452523A5021384155 @default.
- W4309452523 hasAuthorship W4309452523A5021687717 @default.
- W4309452523 hasAuthorship W4309452523A5040695351 @default.
- W4309452523 hasAuthorship W4309452523A5051367687 @default.
- W4309452523 hasAuthorship W4309452523A5051886637 @default.
- W4309452523 hasAuthorship W4309452523A5056923910 @default.
- W4309452523 hasBestOaLocation W43094525231 @default.
- W4309452523 hasConcept C101990758 @default.
- W4309452523 hasConcept C126322002 @default.
- W4309452523 hasConcept C134018914 @default.
- W4309452523 hasConcept C146562846 @default.
- W4309452523 hasConcept C167844969 @default.
- W4309452523 hasConcept C181199279 @default.
- W4309452523 hasConcept C185592680 @default.
- W4309452523 hasConcept C202751555 @default.
- W4309452523 hasConcept C2776033226 @default.
- W4309452523 hasConcept C2776541429 @default.
- W4309452523 hasConcept C55493867 @default.
- W4309452523 hasConcept C673006 @default.
- W4309452523 hasConcept C71924100 @default.
- W4309452523 hasConceptScore W4309452523C101990758 @default.
- W4309452523 hasConceptScore W4309452523C126322002 @default.
- W4309452523 hasConceptScore W4309452523C134018914 @default.
- W4309452523 hasConceptScore W4309452523C146562846 @default.
- W4309452523 hasConceptScore W4309452523C167844969 @default.
- W4309452523 hasConceptScore W4309452523C181199279 @default.
- W4309452523 hasConceptScore W4309452523C185592680 @default.
- W4309452523 hasConceptScore W4309452523C202751555 @default.
- W4309452523 hasConceptScore W4309452523C2776033226 @default.
- W4309452523 hasConceptScore W4309452523C2776541429 @default.
- W4309452523 hasConceptScore W4309452523C55493867 @default.
- W4309452523 hasConceptScore W4309452523C673006 @default.
- W4309452523 hasConceptScore W4309452523C71924100 @default.
- W4309452523 hasLocation W43094525231 @default.
- W4309452523 hasOpenAccess W4309452523 @default.
- W4309452523 hasPrimaryLocation W43094525231 @default.
- W4309452523 hasRelatedWork W1998122353 @default.
- W4309452523 hasRelatedWork W2020087564 @default.
- W4309452523 hasRelatedWork W2070222842 @default.
- W4309452523 hasRelatedWork W2132517007 @default.
- W4309452523 hasRelatedWork W2335610476 @default.
- W4309452523 hasRelatedWork W2345282274 @default.
- W4309452523 hasRelatedWork W2360490775 @default.
- W4309452523 hasRelatedWork W2403179950 @default.
- W4309452523 hasRelatedWork W4286514049 @default.
- W4309452523 hasRelatedWork W4309452523 @default.
- W4309452523 isParatext "false" @default.
- W4309452523 isRetracted "false" @default.
- W4309452523 workType "article" @default.