FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309455544> ?p ?o ?g. }

• W4309455544 endingPage "3650" @default.
• W4309455544 startingPage "3650" @default.
• W4309455544 abstract "Oxidative stress and inflammation damage play pivotal roles in vascular dementia (VaD). Trimethylamine N-oxide (TMAO), an intestinal microbiota-stemming metabolite, was reported to promote inflammation and oxidative stress, involved in the etiology of several diseases. Still, these effects have not been investigated in VaD. Here, we tested whether pre-existing, circulating, high levels of TMAO could affect VaD-induced cognitive decline. TMAO (120 mg/kg) was given to rats for a total of 8 weeks, and these rats underwent a sham operation or bilateral common carotid artery (2VO) surgery after 4 weeks of treatment. Four weeks after surgery, the 2VO rats exhibited hippocampal-dependent cognitive function declines and synaptic plasticity dysfunction, accompanied by an increase in oxidative stress, neuroinflammation, and apoptosis. TMAO administration, which increased plasma and hippocampal TMAO at 4 weeks postoperatively, further aggravated these effects, resulting in exaggerated cognitive and synaptic plasticity impairment, though not within the Sham group. Moreover, TMAO treatment activated the NLRP3 inflammasome and decreased SIRT1 protein expression within the hippocampus. However, these effects of TMAO were significantly attenuated by the overexpression of SIRT1. Our findings suggest that TMAO increases oxidative stress-induced neuroinflammation and apoptosis by inhibiting the SIRT1 pathway, thereby exacerbating cognitive dysfunction and neuropathological changes in VaD rats." @default.
• W4309455544 created "2022-11-28" @default.
• W4309455544 creator A5000128482 @default.
• W4309455544 creator A5010479652 @default.
• W4309455544 creator A5019508076 @default.
• W4309455544 creator A5022721786 @default.
• W4309455544 creator A5036322057 @default.
• W4309455544 creator A5063638708 @default.
• W4309455544 creator A5063732968 @default.
• W4309455544 creator A5091742492 @default.
• W4309455544 date "2022-11-17" @default.
• W4309455544 modified "2023-09-30" @default.
• W4309455544 title "Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats" @default.
• W4309455544 cites W1529674879 @default.
• W4309455544 cites W1667397546 @default.
• W4309455544 cites W1855997172 @default.
• W4309455544 cites W1900968643 @default.
• W4309455544 cites W1991660337 @default.
• W4309455544 cites W1997890651 @default.
• W4309455544 cites W2032057219 @default.
• W4309455544 cites W2051752226 @default.
• W4309455544 cites W2056564149 @default.
• W4309455544 cites W2067722007 @default.
• W4309455544 cites W2068139611 @default.
• W4309455544 cites W2068527344 @default.
• W4309455544 cites W2070325134 @default.
• W4309455544 cites W2070818523 @default.
• W4309455544 cites W2075529906 @default.
• W4309455544 cites W2082857443 @default.
• W4309455544 cites W2106862465 @default.
• W4309455544 cites W2114769428 @default.
• W4309455544 cites W2115944543 @default.
• W4309455544 cites W2121560754 @default.
• W4309455544 cites W2165368743 @default.
• W4309455544 cites W2182357122 @default.
• W4309455544 cites W2299896901 @default.
• W4309455544 cites W2465287431 @default.
• W4309455544 cites W2511525567 @default.
• W4309455544 cites W2523444109 @default.
• W4309455544 cites W2550560946 @default.
• W4309455544 cites W2561876393 @default.
• W4309455544 cites W2566137938 @default.
• W4309455544 cites W2751157908 @default.
• W4309455544 cites W2758846139 @default.
• W4309455544 cites W2759635061 @default.
• W4309455544 cites W2767806634 @default.
• W4309455544 cites W2770392750 @default.
• W4309455544 cites W2783990112 @default.
• W4309455544 cites W2784568242 @default.
• W4309455544 cites W2789702298 @default.
• W4309455544 cites W2793988446 @default.
• W4309455544 cites W2800864806 @default.
• W4309455544 cites W2884965035 @default.
• W4309455544 cites W2892844483 @default.
• W4309455544 cites W2901502912 @default.
• W4309455544 cites W2906377431 @default.
• W4309455544 cites W2937022773 @default.
• W4309455544 cites W2955052897 @default.
• W4309455544 cites W2959751754 @default.
• W4309455544 cites W2966749056 @default.
• W4309455544 cites W2972032017 @default.
• W4309455544 cites W2981163416 @default.
• W4309455544 cites W3034636056 @default.
• W4309455544 cites W3135688628 @default.
• W4309455544 cites W3158716400 @default.
• W4309455544 cites W3162762815 @default.
• W4309455544 cites W3211549368 @default.
• W4309455544 cites W3214266646 @default.
• W4309455544 cites W4221124669 @default.
• W4309455544 doi "https://doi.org/10.3390/cells11223650" @default.
• W4309455544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36429082" @default.
• W4309455544 hasPublicationYear "2022" @default.
• W4309455544 type Work @default.
• W4309455544 citedByCount "2" @default.
• W4309455544 countsByYear W43094555442023 @default.
• W4309455544 crossrefType "journal-article" @default.
• W4309455544 hasAuthorship W4309455544A5000128482 @default.
• W4309455544 hasAuthorship W4309455544A5010479652 @default.
• W4309455544 hasAuthorship W4309455544A5019508076 @default.
• W4309455544 hasAuthorship W4309455544A5022721786 @default.
• W4309455544 hasAuthorship W4309455544A5036322057 @default.
• W4309455544 hasAuthorship W4309455544A5063638708 @default.
• W4309455544 hasAuthorship W4309455544A5063732968 @default.
• W4309455544 hasAuthorship W4309455544A5091742492 @default.
• W4309455544 hasBestOaLocation W43094555441 @default.
• W4309455544 hasConcept C118552586 @default.
• W4309455544 hasConcept C126322002 @default.
• W4309455544 hasConcept C134018914 @default.
• W4309455544 hasConcept C148762608 @default.
• W4309455544 hasConcept C169900460 @default.
• W4309455544 hasConcept C185592680 @default.
• W4309455544 hasConcept C2776149385 @default.
• W4309455544 hasConcept C2776151105 @default.
• W4309455544 hasConcept C2776914184 @default.
• W4309455544 hasConcept C2777952318 @default.
• W4309455544 hasConcept C2779134260 @default.
• W4309455544 hasConcept C2779483572 @default.
• W4309455544 hasConcept C2780043718 @default.

• next