Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309457429> ?p ?o ?g. }
- W4309457429 endingPage "5611" @default.
- W4309457429 startingPage "5611" @default.
- W4309457429 abstract "Glioblastoma multiforme (GBM) is one of the most common types of brain tumor. Despite intensive research, patients with GBM have a poor prognosis due to a very high rate of relapse and significant side effects of the treatment, with a median survival of 14.6 months. Oncolytic viruses are considered a promising strategy to eliminate GBM and other types of cancer, and several viruses have already been introduced into clinical practice. However, identification of the factors that underly the sensitivity of tumor species to oncolytic viruses or that modulate their clinical efficacy remains an important target. Here, we show that Coxsackievirus B5 (CVB5) demonstrates high oncolytic potential towards GBM primary cell species and cell lines. Moreover, 2-deoxyglucose (2DG), an inhibitor of glycolysis, potentiates the cytopathic effects of CVB5 in most of the cancer cell lines tested. The cells in which the inhibition of glycolysis enhanced oncolysis are characterized by high mitochondrial respiratory activity and glycolytic capacity, as determined by Seahorse analysis. Thus, 2-deoxyglucose and other analogs should be considered as adjuvants for oncolytic therapy of glioblastoma multiforme." @default.
- W4309457429 created "2022-11-28" @default.
- W4309457429 creator A5012333682 @default.
- W4309457429 creator A5036147132 @default.
- W4309457429 creator A5043906256 @default.
- W4309457429 creator A5044432696 @default.
- W4309457429 creator A5046172477 @default.
- W4309457429 creator A5063854033 @default.
- W4309457429 creator A5074064892 @default.
- W4309457429 creator A5080372467 @default.
- W4309457429 creator A5081056114 @default.
- W4309457429 creator A5081191206 @default.
- W4309457429 creator A5091703392 @default.
- W4309457429 date "2022-11-15" @default.
- W4309457429 modified "2023-10-15" @default.
- W4309457429 title "2-Deoxyglucose, an Inhibitor of Glycolysis, Enhances the Oncolytic Effect of Coxsackievirus" @default.
- W4309457429 cites W1497063493 @default.
- W4309457429 cites W1597526404 @default.
- W4309457429 cites W1762943369 @default.
- W4309457429 cites W1849819493 @default.
- W4309457429 cites W1964430032 @default.
- W4309457429 cites W1970766774 @default.
- W4309457429 cites W1974254625 @default.
- W4309457429 cites W1992524428 @default.
- W4309457429 cites W2009855429 @default.
- W4309457429 cites W2025697283 @default.
- W4309457429 cites W2029484718 @default.
- W4309457429 cites W2038440293 @default.
- W4309457429 cites W2050711079 @default.
- W4309457429 cites W2055022385 @default.
- W4309457429 cites W2061059838 @default.
- W4309457429 cites W2077633361 @default.
- W4309457429 cites W2081689148 @default.
- W4309457429 cites W2096287682 @default.
- W4309457429 cites W2097308038 @default.
- W4309457429 cites W2100538647 @default.
- W4309457429 cites W2105561184 @default.
- W4309457429 cites W2112804970 @default.
- W4309457429 cites W2121396361 @default.
- W4309457429 cites W2133611748 @default.
- W4309457429 cites W2140327425 @default.
- W4309457429 cites W2149477053 @default.
- W4309457429 cites W2181602822 @default.
- W4309457429 cites W2310799493 @default.
- W4309457429 cites W2340024299 @default.
- W4309457429 cites W2341529963 @default.
- W4309457429 cites W2344480386 @default.
- W4309457429 cites W2346727605 @default.
- W4309457429 cites W2398660216 @default.
- W4309457429 cites W2573765262 @default.
- W4309457429 cites W2592950943 @default.
- W4309457429 cites W2737690243 @default.
- W4309457429 cites W2753126456 @default.
- W4309457429 cites W2772873089 @default.
- W4309457429 cites W2776363019 @default.
- W4309457429 cites W2783126485 @default.
- W4309457429 cites W2795851363 @default.
- W4309457429 cites W2884990513 @default.
- W4309457429 cites W2889085114 @default.
- W4309457429 cites W2891866535 @default.
- W4309457429 cites W2901961906 @default.
- W4309457429 cites W2904990733 @default.
- W4309457429 cites W2943232772 @default.
- W4309457429 cites W2963978412 @default.
- W4309457429 cites W2972205064 @default.
- W4309457429 cites W2974981893 @default.
- W4309457429 cites W2989200690 @default.
- W4309457429 cites W2993990549 @default.
- W4309457429 cites W3004208898 @default.
- W4309457429 cites W3005142833 @default.
- W4309457429 cites W3005502995 @default.
- W4309457429 cites W3031224726 @default.
- W4309457429 cites W3092306917 @default.
- W4309457429 cites W3093419479 @default.
- W4309457429 cites W3112987623 @default.
- W4309457429 cites W3113586813 @default.
- W4309457429 cites W3126562453 @default.
- W4309457429 cites W3127383553 @default.
- W4309457429 cites W3129075231 @default.
- W4309457429 cites W3144540302 @default.
- W4309457429 cites W3153317009 @default.
- W4309457429 cites W3158142088 @default.
- W4309457429 cites W3160424869 @default.
- W4309457429 cites W3169005305 @default.
- W4309457429 cites W3184487460 @default.
- W4309457429 cites W3206651739 @default.
- W4309457429 cites W3210054708 @default.
- W4309457429 cites W3214173072 @default.
- W4309457429 cites W4205430135 @default.
- W4309457429 cites W4206669084 @default.
- W4309457429 cites W4226397832 @default.
- W4309457429 cites W4229013530 @default.
- W4309457429 cites W4229336470 @default.
- W4309457429 cites W4286203231 @default.
- W4309457429 cites W4286488544 @default.
- W4309457429 cites W4286492761 @default.
- W4309457429 cites W4289755149 @default.
- W4309457429 cites W4293101997 @default.