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• W4309457789 abstract "The Calcium-Sensing Receptor (CaSR) is a member of the class C of G-proteins coupled receptors (GPCRs), it plays a pivotal role in calcium homeostasis by directly controlling calcium excretion in the kidneys and indirectly by regulating parathyroid hormone (PTH) release from the parathyroid glands. The CaSR is found to be ubiquitously expressed in the body, playing a plethora of additional functions spanning from fluid secretion, insulin release, neuronal development, vessel tone to cell proliferation and apoptosis, to name but a few. The present review aims to elucidate and clarify the emerging regulatory effects that the CaSR plays in inflammation in several tissues, where it mostly promotes pro-inflammatory responses, with the exception of the large intestine, where contradictory roles have been recently reported. The CaSR has been found to be expressed even in immune cells, where it stimulates immune response and chemokinesis. On the other hand, CaSR expression seems to be boosted under inflammatory stimulus, in particular, by pro-inflammatory cytokines. Because of this, the CaSR has been addressed as a key factor responsible for hypocalcemia and low levels of PTH that are commonly found in critically ill patients under sepsis or after burn injury. Moreover, the CaSR has been found to be implicated in autoimmune-hypoparathyroidism, recently found also in patients treated with immune-checkpoint inhibitors. Given the tight bound between the CaSR, calcium and vitamin D metabolism, we also speculate about their roles in the pathogenesis of severe acute respiratory syndrome coronavirus-19 (SARS-COVID-19) infection and their impact on patients’ prognosis. We will further explore the therapeutic potential of pharmacological targeting of the CaSR for the treatment and management of aberrant inflammatory responses." @default.
• W4309457789 created "2022-11-28" @default.
• W4309457789 creator A5055069129 @default.
• W4309457789 creator A5089703803 @default.
• W4309457789 date "2022-11-18" @default.
• W4309457789 modified "2023-10-03" @default.
• W4309457789 title "The calcium-sensing receptor in inflammation: Recent updates" @default.
• W4309457789 cites W1167592479 @default.
• W4309457789 cites W1485297825 @default.
• W4309457789 cites W1491862190 @default.
• W4309457789 cites W1510076229 @default.
• W4309457789 cites W1519019390 @default.
• W4309457789 cites W1549316628 @default.
• W4309457789 cites W1831122790 @default.
• W4309457789 cites W1966158331 @default.
• W4309457789 cites W1968871420 @default.
• W4309457789 cites W1968988904 @default.
• W4309457789 cites W1969379479 @default.
• W4309457789 cites W1969540263 @default.
• W4309457789 cites W1971314625 @default.
• W4309457789 cites W1977441177 @default.
• W4309457789 cites W1977451393 @default.
• W4309457789 cites W1980783902 @default.
• W4309457789 cites W1984453279 @default.
• W4309457789 cites W1986046059 @default.
• W4309457789 cites W1986593715 @default.
• W4309457789 cites W1987329700 @default.
• W4309457789 cites W1990744267 @default.
• W4309457789 cites W1993385307 @default.
• W4309457789 cites W1996270959 @default.
• W4309457789 cites W1998911142 @default.
• W4309457789 cites W2002134267 @default.
• W4309457789 cites W2005539167 @default.
• W4309457789 cites W2006975269 @default.
• W4309457789 cites W2007618187 @default.
• W4309457789 cites W2009441758 @default.
• W4309457789 cites W2010052045 @default.
• W4309457789 cites W2012222934 @default.
• W4309457789 cites W2012676982 @default.
• W4309457789 cites W2012927900 @default.
• W4309457789 cites W2013997932 @default.
• W4309457789 cites W2017161591 @default.
• W4309457789 cites W2018426493 @default.
• W4309457789 cites W2019428080 @default.
• W4309457789 cites W2021681940 @default.
• W4309457789 cites W2022820753 @default.
• W4309457789 cites W2022884961 @default.
• W4309457789 cites W2028030386 @default.
• W4309457789 cites W2028418794 @default.
• W4309457789 cites W2031155993 @default.
• W4309457789 cites W2033053933 @default.
• W4309457789 cites W2033489858 @default.
• W4309457789 cites W2035469386 @default.
• W4309457789 cites W2036145275 @default.
• W4309457789 cites W2047185204 @default.
• W4309457789 cites W2047688044 @default.
• W4309457789 cites W2050963795 @default.
• W4309457789 cites W2054862901 @default.
• W4309457789 cites W2056312916 @default.
• W4309457789 cites W2066854584 @default.
• W4309457789 cites W2067866614 @default.
• W4309457789 cites W2069411599 @default.
• W4309457789 cites W2071517838 @default.
• W4309457789 cites W2074117503 @default.
• W4309457789 cites W2074345156 @default.
• W4309457789 cites W2079711215 @default.
• W4309457789 cites W2082111812 @default.
• W4309457789 cites W2083169698 @default.
• W4309457789 cites W2084012541 @default.
• W4309457789 cites W2093896590 @default.
• W4309457789 cites W2098661964 @default.
• W4309457789 cites W2101493105 @default.
• W4309457789 cites W2102800827 @default.
• W4309457789 cites W2102838234 @default.
• W4309457789 cites W2104601022 @default.
• W4309457789 cites W2110901553 @default.
• W4309457789 cites W2112594020 @default.
• W4309457789 cites W2113286739 @default.
• W4309457789 cites W2113963609 @default.
• W4309457789 cites W2115476261 @default.
• W4309457789 cites W2116612370 @default.
• W4309457789 cites W2118207659 @default.
• W4309457789 cites W2121448352 @default.
• W4309457789 cites W2121830956 @default.
• W4309457789 cites W2123085104 @default.
• W4309457789 cites W2130526265 @default.
• W4309457789 cites W2136610376 @default.
• W4309457789 cites W2136991956 @default.
• W4309457789 cites W2137133055 @default.
• W4309457789 cites W2138779981 @default.
• W4309457789 cites W2139814523 @default.
• W4309457789 cites W2140096924 @default.
• W4309457789 cites W2143742516 @default.
• W4309457789 cites W2146684396 @default.
• W4309457789 cites W2147575334 @default.
• W4309457789 cites W2148563793 @default.
• W4309457789 cites W2159907329 @default.
• W4309457789 cites W2167820185 @default.
• W4309457789 cites W2170949021 @default.
• W4309457789 cites W2171810658 @default.

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