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• W4309458839 abstract "SARS-CoV-2 has become a global threat to public health. Infected individuals can be asymptomatic or develop mild to severe symptoms, including pneumonia, respiratory distress, and death. This wide spectrum of clinical presentations of SARS-CoV-2 infection is believed in part due to the polymorphisms of key genetic factors in the population. In this study, we report that the interferon-induced antiviral factor IFITM3 inhibits SARS-CoV-2 infection by preventing SARS-CoV-2 spike-protein-mediated virus entry and cell-to-cell fusion. Analysis of a Chinese COVID-19 patient cohort demonstrates that the rs12252 CC genotype of IFITM3 is associated with SARS-CoV-2 infection risk in the studied cohort. These data suggest that individuals carrying the rs12252 C allele in the IFITM3 gene may be vulnerable to SARS-CoV-2 infection and thus may benefit from early medical intervention." @default.
• W4309458839 created "2022-11-28" @default.
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• W4309458839 date "2022-11-18" @default.
• W4309458839 modified "2023-10-16" @default.
• W4309458839 title "IFITM3 Inhibits SARS-CoV-2 Infection and Is Associated with COVID-19 Susceptibility" @default.
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• W4309458839 doi "https://doi.org/10.3390/v14112553" @default.
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