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- W4309459249 endingPage "2491" @default.
- W4309459249 startingPage "2491" @default.
- W4309459249 abstract "The advent of skin patch formulation design and technology has enabled the commercialisation of methyl salicylate (MS) as a topical patch. However, the most fundamental aspect of skin permeation is unknown at present. The study aims to investigate the effect of solvent choice on the skin permeation of MS in a neat solvent system and patch formulation with an emphasis on patch adhesion. MS in six selected solvents (propylene glycol (PG), Transcutol®, isopropyl myristate, Labrasol®, Plurol® oleique CC 497 and Maisine® CC) was characterised and in vitro permeation studies were also performed. An ATR-FTIR analysis on solvent-treated skin was conudcted. Patch formulation was prepared and characterised for adhesion, in vitro drug release and skin permeation studies. The highest MS permeation was found in neat PG over 24 h (~90 μg/cm2) due to its strong skin protein conformation effect. Transcutol® and isopropyl myristate showed better skin deposition and formulation retention, respectively. Nevertheless, PG enhanced the patch adhesion despite having a lower cumulative amount of MS permeated (~80 μg/cm2) as compared with Transcutol® and Maisine® (~110–150 μg/cm2). These two solvents, however, demonstrated better skin deposition and formulation retention but a lower patch adhesion. The unpredictable influence of the solvent on patch adhesion highlights the importance of the trade-off between patch adhesion and skin permeation during formulation design." @default.
- W4309459249 created "2022-11-28" @default.
- W4309459249 creator A5003899992 @default.
- W4309459249 creator A5066523846 @default.
- W4309459249 creator A5080724828 @default.
- W4309459249 creator A5089016927 @default.
- W4309459249 date "2022-11-17" @default.
- W4309459249 modified "2023-09-25" @default.
- W4309459249 title "Development and Characterisation of a Topical Methyl Salicylate Patch: Effect of Solvents on Adhesion and Skin Permeation" @default.
- W4309459249 cites W1494615854 @default.
- W4309459249 cites W1523241913 @default.
- W4309459249 cites W1550486614 @default.
- W4309459249 cites W1568759573 @default.
- W4309459249 cites W1712912973 @default.
- W4309459249 cites W1726311165 @default.
- W4309459249 cites W1965380106 @default.
- W4309459249 cites W1969414369 @default.
- W4309459249 cites W1972471925 @default.
- W4309459249 cites W1976735586 @default.
- W4309459249 cites W1978061895 @default.
- W4309459249 cites W1978537309 @default.
- W4309459249 cites W1986444327 @default.
- W4309459249 cites W1986599287 @default.
- W4309459249 cites W1988302636 @default.
- W4309459249 cites W1991433394 @default.
- W4309459249 cites W1991834753 @default.
- W4309459249 cites W1993243150 @default.
- W4309459249 cites W1993778788 @default.
- W4309459249 cites W1994297413 @default.
- W4309459249 cites W2001432281 @default.
- W4309459249 cites W2002218627 @default.
- W4309459249 cites W2009802176 @default.
- W4309459249 cites W2011601042 @default.
- W4309459249 cites W2014743489 @default.
- W4309459249 cites W2017225673 @default.
- W4309459249 cites W2017395821 @default.
- W4309459249 cites W2025009992 @default.
- W4309459249 cites W2038309565 @default.
- W4309459249 cites W2038651950 @default.
- W4309459249 cites W2042831554 @default.
- W4309459249 cites W2046667253 @default.
- W4309459249 cites W2048285762 @default.
- W4309459249 cites W2048404933 @default.
- W4309459249 cites W2052218150 @default.
- W4309459249 cites W2055278139 @default.
- W4309459249 cites W2055358289 @default.
- W4309459249 cites W2056205702 @default.
- W4309459249 cites W2057199765 @default.
- W4309459249 cites W2057487768 @default.
- W4309459249 cites W2058745619 @default.
- W4309459249 cites W2059384239 @default.
- W4309459249 cites W2059484536 @default.
- W4309459249 cites W2063851526 @default.
- W4309459249 cites W2063854835 @default.
- W4309459249 cites W2064805272 @default.
- W4309459249 cites W2071238217 @default.
- W4309459249 cites W2074749041 @default.
- W4309459249 cites W2081674091 @default.
- W4309459249 cites W2083691925 @default.
- W4309459249 cites W2087445597 @default.
- W4309459249 cites W2089782352 @default.
- W4309459249 cites W2093950592 @default.
- W4309459249 cites W2102396731 @default.
- W4309459249 cites W2105873857 @default.
- W4309459249 cites W2113966037 @default.
- W4309459249 cites W2146117780 @default.
- W4309459249 cites W2147072983 @default.
- W4309459249 cites W2152312983 @default.
- W4309459249 cites W2157286284 @default.
- W4309459249 cites W2171119351 @default.
- W4309459249 cites W2189825432 @default.
- W4309459249 cites W2407287133 @default.
- W4309459249 cites W2417228936 @default.
- W4309459249 cites W2473140479 @default.
- W4309459249 cites W2581762208 @default.
- W4309459249 cites W2600344469 @default.
- W4309459249 cites W2601669084 @default.
- W4309459249 cites W2614097531 @default.
- W4309459249 cites W2738562389 @default.
- W4309459249 cites W2793635180 @default.
- W4309459249 cites W2803395614 @default.
- W4309459249 cites W2804203378 @default.
- W4309459249 cites W2806723960 @default.
- W4309459249 cites W2806789751 @default.
- W4309459249 cites W2844121721 @default.
- W4309459249 cites W2900637971 @default.
- W4309459249 cites W2905290371 @default.
- W4309459249 cites W2958381338 @default.
- W4309459249 cites W2972115387 @default.
- W4309459249 cites W2972820369 @default.
- W4309459249 cites W3000668256 @default.
- W4309459249 cites W3006398046 @default.
- W4309459249 cites W3010834283 @default.
- W4309459249 cites W3040740594 @default.
- W4309459249 cites W3041085752 @default.
- W4309459249 cites W3049013750 @default.
- W4309459249 cites W3109939744 @default.
- W4309459249 cites W3130238153 @default.