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- W4309459614 abstract "As an important component of the innate immune system, natural killer (NK) cells have gained increasing attention in adoptive cell therapy for their safety and efficacious tumor-killing effect. Unlike T cells which rely on the interaction between TCRs and specific peptide-MHC complexes, NK cells are more prone to be served as off-the-shelf cell therapy products due to their rapid recognition and killing of tumor cells without MHC restriction. In recent years, constantly emerging sources of therapeutic NK cells have provided flexible options for cancer immunotherapy. Advanced genetic engineering techniques, especially chimeric antigen receptor (CAR) modification, have yielded exciting effectiveness in enhancing NK cell specificity and cytotoxicity, improving in vivo persistence, and overcoming immunosuppressive factors derived from tumors. In this review, we highlight current advances in NK-based adoptive cell therapy, including alternative sources of NK cells for adoptive infusion, various CAR modifications that confer different targeting specificity to NK cells, multiple genetic engineering strategies to enhance NK cell function, as well as the latest clinical research on adoptive NK cell therapy." @default.
- W4309459614 created "2022-11-28" @default.
- W4309459614 creator A5018894398 @default.
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- W4309459614 creator A5045207101 @default.
- W4309459614 creator A5055420643 @default.
- W4309459614 creator A5058062676 @default.
- W4309459614 date "2022-11-17" @default.
- W4309459614 modified "2023-10-14" @default.
- W4309459614 title "Natural Killer Cells: A Promising Kit in the Adoptive Cell Therapy Toolbox" @default.
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