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• W4309467087 abstract "<ns4:p><ns4:bold>Background</ns4:bold></ns4:p><ns4:p> In COVID-19, the release of pro-inflammatory mediators in the cytokine storm, primarily interleukin-6 (IL-6), has been hypothesized to induce pulmonary intravascular coagulation. However, the relationship between IL-6 and coagulopathy remains unclear in COVID-19 progression.<ns4:bold> </ns4:bold>We aimed to investigate the correlation of IL-6 with D-dimer, fibrinogen, prothrombin time (PT), and ferritin. Furthermore, we also analyzed the effect of those parameters on the worsening of COVID-19 patients.</ns4:p><ns4:p> </ns4:p><ns4:p> <ns4:bold>M</ns4:bold><ns4:bold>etho</ns4:bold><ns4:bold>ds</ns4:bold></ns4:p><ns4:p> A prospective cohort study was conducted in moderate and severe COVID-19 patients from June 2020 to January 2021. A serial evaluation of IL-6, D-dimer, fibrinogen, ferritin, and PT was performed and correlated with the patient's condition at admission and on the 14th day. The outcomes (improvement, worsening, or discharged patients) were recorded during the study.</ns4:p><ns4:p> </ns4:p><ns4:p> <ns4:bold>Results</ns4:bold></ns4:p><ns4:p> Of 374 patients, 73 study subjects (61 severe and 12 moderate COVID-19) were included in this study. A total of 35 out of 61 severe and one out of 12 moderate illness subjects had experienced worsening. Spearman-rank correlation of IL-6 with with ferritin, D-dimer, fibrinogen, and PT was 0.08 (<ns4:italic>p</ns4:italic>=0.5), −0.13 (<ns4:italic>p</ns4:italic>=0.27), 0.01 (<ns4:italic>p</ns4:italic>=0.91), and 0.03 (<ns4:italic>p</ns4:italic>=0.77), respectively. In ROC analysis, D-dimer (74,77%) and IL-6 (71,32%) were the highest among other variables (>60%).</ns4:p><ns4:p> </ns4:p><ns4:p> <ns4:bold>Conclusions</ns4:bold></ns4:p><ns4:p> In COVID-19 patients, there was a correlation between elevated IL-6 and D-dimer levels with disease deterioration. There was no correlation between elevated IL-6 levels with ferritin, D-dimer, fibrinogen, and PT levels. Therefore, changes in IL-6 and D-dimer can predict worsening in moderate and severe COVID-19 patients.</ns4:p>" @default.
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• W4309467087 date "2022-11-10" @default.
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• W4309467087 title "The role of IL-6, ferritin, and coagulopathy in COVID-19 clinical progression" @default.
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