Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309470006> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4309470006 endingPage "105290" @default.
- W4309470006 startingPage "105290" @default.
- W4309470006 abstract "Physiologically based pharmacokinetic (PBPK) models are a means of making important linkages between exposure assessment and in vitro toxicity. A key constraint on rapid application of PBPK models in risk assessment is traditional reliance on substance-specific in vivo toxicokinetic data to evaluate model quality. Bounding conditions, in silico, in vitro, and chemical read-across approaches have been proposed as alternative sources for metabolic clearance estimates. A case study to test consistency of predictive ability across these approaches was conducted using trimethylbenzenes (TMB) as prototype chemicals. Substantial concordance was found among TMB isomers with respect to accuracy (or inaccuracy) of approaches to estimating metabolism; for example, the bounding conditions never reproduced the human in vivo toxicokinetic data within two-fold. Using only approaches that gave acceptable prediction of in vivo toxicokinetics for the source compound (1,2,4-TMB) substantially narrowed the range of plausible internal doses for a given external dose for occupational, emergency response, and environmental/community health risk assessment scenarios for TMB isomers. Thus, risk assessments developed using the target compound models with a constrained subset of metabolism estimates (determined for source chemical models) can be used with greater confidence that internal dosimetry will be estimated with accuracy sufficient for the purpose at hand." @default.
- W4309470006 created "2022-11-28" @default.
- W4309470006 creator A5021548189 @default.
- W4309470006 date "2022-12-01" @default.
- W4309470006 modified "2023-10-16" @default.
- W4309470006 title "Correct calculations of a “safe” daily dose of raw materials for homeopathic remedies. Re: Toxicological assessment compilation of selected examples of raw materials for homeopathic and anthroposophic medicinal products - Part 2. Regulatory Toxicology and Pharmacology, 2022. 134" @default.
- W4309470006 cites W2030619957 @default.
- W4309470006 cites W2912601258 @default.
- W4309470006 doi "https://doi.org/10.1016/j.yrtph.2022.105290" @default.
- W4309470006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36400281" @default.
- W4309470006 hasPublicationYear "2022" @default.
- W4309470006 type Work @default.
- W4309470006 citedByCount "1" @default.
- W4309470006 countsByYear W43094700062023 @default.
- W4309470006 crossrefType "journal-article" @default.
- W4309470006 hasAuthorship W4309470006A5021548189 @default.
- W4309470006 hasConcept C104317684 @default.
- W4309470006 hasConcept C112705442 @default.
- W4309470006 hasConcept C12174686 @default.
- W4309470006 hasConcept C127413603 @default.
- W4309470006 hasConcept C183696295 @default.
- W4309470006 hasConcept C185592680 @default.
- W4309470006 hasConcept C185867374 @default.
- W4309470006 hasConcept C195289149 @default.
- W4309470006 hasConcept C2775905019 @default.
- W4309470006 hasConcept C33070731 @default.
- W4309470006 hasConcept C38652104 @default.
- W4309470006 hasConcept C41008148 @default.
- W4309470006 hasConcept C55493867 @default.
- W4309470006 hasConcept C71924100 @default.
- W4309470006 hasConcept C86803240 @default.
- W4309470006 hasConcept C98274493 @default.
- W4309470006 hasConceptScore W4309470006C104317684 @default.
- W4309470006 hasConceptScore W4309470006C112705442 @default.
- W4309470006 hasConceptScore W4309470006C12174686 @default.
- W4309470006 hasConceptScore W4309470006C127413603 @default.
- W4309470006 hasConceptScore W4309470006C183696295 @default.
- W4309470006 hasConceptScore W4309470006C185592680 @default.
- W4309470006 hasConceptScore W4309470006C185867374 @default.
- W4309470006 hasConceptScore W4309470006C195289149 @default.
- W4309470006 hasConceptScore W4309470006C2775905019 @default.
- W4309470006 hasConceptScore W4309470006C33070731 @default.
- W4309470006 hasConceptScore W4309470006C38652104 @default.
- W4309470006 hasConceptScore W4309470006C41008148 @default.
- W4309470006 hasConceptScore W4309470006C55493867 @default.
- W4309470006 hasConceptScore W4309470006C71924100 @default.
- W4309470006 hasConceptScore W4309470006C86803240 @default.
- W4309470006 hasConceptScore W4309470006C98274493 @default.
- W4309470006 hasLocation W43094700061 @default.
- W4309470006 hasLocation W43094700062 @default.
- W4309470006 hasOpenAccess W4309470006 @default.
- W4309470006 hasPrimaryLocation W43094700061 @default.
- W4309470006 hasRelatedWork W1189217705 @default.
- W4309470006 hasRelatedWork W2086209760 @default.
- W4309470006 hasRelatedWork W2113116302 @default.
- W4309470006 hasRelatedWork W2499652375 @default.
- W4309470006 hasRelatedWork W2889499865 @default.
- W4309470006 hasRelatedWork W2966093382 @default.
- W4309470006 hasRelatedWork W4210823161 @default.
- W4309470006 hasRelatedWork W4297964896 @default.
- W4309470006 hasRelatedWork W4307454629 @default.
- W4309470006 hasRelatedWork W4309724058 @default.
- W4309470006 hasVolume "136" @default.
- W4309470006 isParatext "false" @default.
- W4309470006 isRetracted "false" @default.
- W4309470006 workType "article" @default.