Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309472553> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4309472553 endingPage "S187" @default.
- W4309472553 startingPage "S187" @default.
- W4309472553 abstract "Pathogenic memory T cells are implicated in the local memory of chronic skin diseases. The factors underlying their persistence and function in human resolved epidermis are not understood. Lipid composition and transcriptional programs of lipid metabolism are known to be altered in active and non-lesional psoriasis, and the faculty of resident T cells to uptake fatty acids is essential to their local survival. Here, we wished to correlate the functionality of epidermal T cells in resolved skin of psoriasis patients to the lipid metabolism using transcriptomic data. Skin biopsies from patients with psoriasis were collected both on resolved and non-involved (non-lesional) areas, as well as in healthy controls. Flow cytometry was performed on epidermal cell suspension of healthy controls, with assessment of T cell surface markers and cytokine production. T cells were activated in skin explants with the pan T-cell agonist OKT-3 compared to an IgG2a control. The RNA purified from the epidermal compartment was analyzed by a custom panel from Nanostring focused on inflammatory markers and lipid metabolism. In healthy epidermis, the proportion of cells expressing the checkpoint inhibitor PD1+ among T cells was negatively correlated to the expression of the transcripts LTB4R and PTGES2 suggesting their involvement in the immune regulation. LTB4R is a receptor of the pro-inflammatory leukotriene LTB4 and its expression was decreased in resolved epidermis compared to non-lesional skin. Furthermore, ex vivo activation of T cells in resolved psoriasis but not in non-lesional epidermis induced IL10 and IDO1 and the level of this upregulation was positively correlated to the baseline level of LTB4R. Altogether, our data suggest a link between the level of expression of LTB4R and the immune regulation present in the resolved psoriasis epidermis." @default.
- W4309472553 created "2022-11-28" @default.
- W4309472553 creator A5012008353 @default.
- W4309472553 creator A5018575098 @default.
- W4309472553 creator A5039520063 @default.
- W4309472553 creator A5044024585 @default.
- W4309472553 creator A5045653861 @default.
- W4309472553 creator A5085345169 @default.
- W4309472553 date "2022-12-01" @default.
- W4309472553 modified "2023-09-25" @default.
- W4309472553 title "042 Epidermal leucotriene B4 receptor expression as a marker of regulatory T-cell–driven responses in resolved psoriasis" @default.
- W4309472553 doi "https://doi.org/10.1016/j.jid.2022.09.051" @default.
- W4309472553 hasPublicationYear "2022" @default.
- W4309472553 type Work @default.
- W4309472553 citedByCount "0" @default.
- W4309472553 crossrefType "journal-article" @default.
- W4309472553 hasAuthorship W4309472553A5012008353 @default.
- W4309472553 hasAuthorship W4309472553A5018575098 @default.
- W4309472553 hasAuthorship W4309472553A5039520063 @default.
- W4309472553 hasAuthorship W4309472553A5044024585 @default.
- W4309472553 hasAuthorship W4309472553A5045653861 @default.
- W4309472553 hasAuthorship W4309472553A5085345169 @default.
- W4309472553 hasBestOaLocation W43094725531 @default.
- W4309472553 hasConcept C105702510 @default.
- W4309472553 hasConcept C134018914 @default.
- W4309472553 hasConcept C170493617 @default.
- W4309472553 hasConcept C203014093 @default.
- W4309472553 hasConcept C2776090121 @default.
- W4309472553 hasConcept C2776458125 @default.
- W4309472553 hasConcept C2776914184 @default.
- W4309472553 hasConcept C2777074287 @default.
- W4309472553 hasConcept C2778690821 @default.
- W4309472553 hasConcept C2780564577 @default.
- W4309472553 hasConcept C4733338 @default.
- W4309472553 hasConcept C502942594 @default.
- W4309472553 hasConcept C54355233 @default.
- W4309472553 hasConcept C553184892 @default.
- W4309472553 hasConcept C55493867 @default.
- W4309472553 hasConcept C81885089 @default.
- W4309472553 hasConcept C86803240 @default.
- W4309472553 hasConcept C8891405 @default.
- W4309472553 hasConcept C95444343 @default.
- W4309472553 hasConceptScore W4309472553C105702510 @default.
- W4309472553 hasConceptScore W4309472553C134018914 @default.
- W4309472553 hasConceptScore W4309472553C170493617 @default.
- W4309472553 hasConceptScore W4309472553C203014093 @default.
- W4309472553 hasConceptScore W4309472553C2776090121 @default.
- W4309472553 hasConceptScore W4309472553C2776458125 @default.
- W4309472553 hasConceptScore W4309472553C2776914184 @default.
- W4309472553 hasConceptScore W4309472553C2777074287 @default.
- W4309472553 hasConceptScore W4309472553C2778690821 @default.
- W4309472553 hasConceptScore W4309472553C2780564577 @default.
- W4309472553 hasConceptScore W4309472553C4733338 @default.
- W4309472553 hasConceptScore W4309472553C502942594 @default.
- W4309472553 hasConceptScore W4309472553C54355233 @default.
- W4309472553 hasConceptScore W4309472553C553184892 @default.
- W4309472553 hasConceptScore W4309472553C55493867 @default.
- W4309472553 hasConceptScore W4309472553C81885089 @default.
- W4309472553 hasConceptScore W4309472553C86803240 @default.
- W4309472553 hasConceptScore W4309472553C8891405 @default.
- W4309472553 hasConceptScore W4309472553C95444343 @default.
- W4309472553 hasIssue "12" @default.
- W4309472553 hasLocation W43094725531 @default.
- W4309472553 hasOpenAccess W4309472553 @default.
- W4309472553 hasPrimaryLocation W43094725531 @default.
- W4309472553 hasRelatedWork W2038343441 @default.
- W4309472553 hasRelatedWork W2046921917 @default.
- W4309472553 hasRelatedWork W2047209980 @default.
- W4309472553 hasRelatedWork W2081574416 @default.
- W4309472553 hasRelatedWork W2090052656 @default.
- W4309472553 hasRelatedWork W2113817581 @default.
- W4309472553 hasRelatedWork W2377214929 @default.
- W4309472553 hasRelatedWork W4296449097 @default.
- W4309472553 hasRelatedWork W4309472553 @default.
- W4309472553 hasRelatedWork W4309482936 @default.
- W4309472553 hasVolume "142" @default.
- W4309472553 isParatext "false" @default.
- W4309472553 isRetracted "false" @default.
- W4309472553 workType "article" @default.