FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309473602> ?p ?o ?g. }

• W4309473602 abstract "Imbalance of gut microbiota homeostasis is related to the occurrence of ulcerative colitis (UC), and probiotics are thought to modulate immune microenvironment and repair barrier function. Here, in order to reveal the interaction between UC and gut microbiota, we screened a new probiotic strain by 16S rRNA sequencing from Dextran Sulfate Sodium (DSS)-induced colitis mice, and explored the mechanism and clinical relevance. Lactobacillus johnsonii (L. johnsonii), as a potential anti-inflammatory bacterium was decreased colonization in colitis mice. Gavage L. johnsonii could alleviate colitis by specifically increasing the proportion of intestinal macrophages and the secretion of Il-10 with macrophages depleted model and in Il10-/- mice. We identified this subset of immune cells activated by L. johnsonii as CD206+ macrophagesIL-10. Mechanistically, L. johnsonii supplementation enhanced the mobilization of CD206+ macrophagesIL-10 through the activation of STAT3 in vivo and in vitro. In addition, we revealed that TLR1/2 was essential for the activation of STAT3 and the recognition of L. johnsonii by macrophages. Clinically, there was positive correlation between the abundance of L. johnsonii and the expression level of MRC1, IL10 and TLR1/2 in UC tissues. L. johnsonii could activate native macrophages into CD206+ macrophages and release IL-10 through TLR1/2-STAT3 pathway to relieve experimental colitis. L. johnsonii may serve as an immunomodulator and anti-inflammatory therapeutic target for UC." @default.
• W4309473602 created "2022-11-28" @default.
• W4309473602 creator A5004228795 @default.
• W4309473602 creator A5017223380 @default.
• W4309473602 creator A5021120060 @default.
• W4309473602 creator A5023030471 @default.
• W4309473602 creator A5025075819 @default.
• W4309473602 creator A5025262442 @default.
• W4309473602 creator A5028859676 @default.
• W4309473602 creator A5034691462 @default.
• W4309473602 creator A5035364186 @default.
• W4309473602 creator A5039490661 @default.
• W4309473602 creator A5040175888 @default.
• W4309473602 creator A5042973046 @default.
• W4309473602 creator A5052964209 @default.
• W4309473602 creator A5058096961 @default.
• W4309473602 creator A5058990485 @default.
• W4309473602 creator A5073567490 @default.
• W4309473602 creator A5079459702 @default.
• W4309473602 creator A5082487695 @default.
• W4309473602 creator A5085772770 @default.
• W4309473602 date "2022-11-18" @default.
• W4309473602 modified "2023-10-11" @default.
• W4309473602 title "<i>Lactobacillus johnsonii</i> alleviates colitis by TLR1/2-STAT3 mediated CD206⁺ macrophages^IL-10 activation" @default.
• W4309473602 cites W174130975 @default.
• W4309473602 cites W1817506593 @default.
• W4309473602 cites W1976611079 @default.
• W4309473602 cites W2004465286 @default.
• W4309473602 cites W2009054323 @default.
• W4309473602 cites W2033119740 @default.
• W4309473602 cites W2054100516 @default.
• W4309473602 cites W2067359484 @default.
• W4309473602 cites W2075537545 @default.
• W4309473602 cites W2078165843 @default.
• W4309473602 cites W2078621117 @default.
• W4309473602 cites W2095652087 @default.
• W4309473602 cites W2110768898 @default.
• W4309473602 cites W2117525838 @default.
• W4309473602 cites W2148579227 @default.
• W4309473602 cites W2148770916 @default.
• W4309473602 cites W2152765405 @default.
• W4309473602 cites W2159560463 @default.
• W4309473602 cites W2162654167 @default.
• W4309473602 cites W2201859789 @default.
• W4309473602 cites W2529692498 @default.
• W4309473602 cites W2553776454 @default.
• W4309473602 cites W2582487809 @default.
• W4309473602 cites W2736839127 @default.
• W4309473602 cites W2792345410 @default.
• W4309473602 cites W2803277749 @default.
• W4309473602 cites W2809122762 @default.
• W4309473602 cites W2884367937 @default.
• W4309473602 cites W2894545436 @default.
• W4309473602 cites W2905827542 @default.
• W4309473602 cites W2923227879 @default.
• W4309473602 cites W2931716796 @default.
• W4309473602 cites W2963622568 @default.
• W4309473602 cites W2998718302 @default.
• W4309473602 cites W3012283572 @default.
• W4309473602 cites W3012377065 @default.
• W4309473602 cites W3022747103 @default.
• W4309473602 cites W3025018074 @default.
• W4309473602 cites W3037945517 @default.
• W4309473602 cites W3041326403 @default.
• W4309473602 cites W3049328559 @default.
• W4309473602 cites W3086885273 @default.
• W4309473602 cites W3090585618 @default.
• W4309473602 cites W3090744476 @default.
• W4309473602 cites W3092964339 @default.
• W4309473602 cites W3096586635 @default.
• W4309473602 cites W3126436367 @default.
• W4309473602 cites W3135922797 @default.
• W4309473602 cites W3191340659 @default.
• W4309473602 cites W3195876720 @default.
• W4309473602 cites W3202542272 @default.
• W4309473602 cites W3203871149 @default.
• W4309473602 cites W3206269369 @default.
• W4309473602 cites W3210305078 @default.
• W4309473602 cites W4210972027 @default.
• W4309473602 cites W4211156615 @default.
• W4309473602 cites W4213245349 @default.
• W4309473602 cites W4226343974 @default.
• W4309473602 cites W4230633180 @default.
• W4309473602 doi "https://doi.org/10.1080/19490976.2022.2145843" @default.
• W4309473602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36398889" @default.
• W4309473602 hasPublicationYear "2022" @default.
• W4309473602 type Work @default.
• W4309473602 citedByCount "6" @default.
• W4309473602 countsByYear W43094736022023 @default.
• W4309473602 crossrefType "journal-article" @default.
• W4309473602 hasAuthorship W4309473602A5004228795 @default.
• W4309473602 hasAuthorship W4309473602A5017223380 @default.
• W4309473602 hasAuthorship W4309473602A5021120060 @default.
• W4309473602 hasAuthorship W4309473602A5023030471 @default.
• W4309473602 hasAuthorship W4309473602A5025075819 @default.
• W4309473602 hasAuthorship W4309473602A5025262442 @default.
• W4309473602 hasAuthorship W4309473602A5028859676 @default.
• W4309473602 hasAuthorship W4309473602A5034691462 @default.
• W4309473602 hasAuthorship W4309473602A5035364186 @default.
• W4309473602 hasAuthorship W4309473602A5039490661 @default.

• next