Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309476875> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4309476875 endingPage "S210" @default.
- W4309476875 startingPage "S210" @default.
- W4309476875 abstract "The skin epidermis is transformed during development, through stratification and differentiation, from a simple single-layered epithelium into a complex barrier just before birth. However, how epidermal stratification and the switch in cell fate from the basal to suprabasal keratinocytes are achieved at the molecular level remain elusive. Understanding the crucial cell fate switch is important for designing therapies for hyperproliferative human skin diseases such as psoriasis or atopic dermatitis, which may recapitulate developmental programs. Using dynamic growth and tissue measurements in the mouse, we recently proposed a two-phase model of epidermal stratification and development. In the first phase, the epidermal progenitors undergo a burst in proliferation around embryonic day E13.5 that leads to crowding in the basal layer and the onset of stratification, where cells are pushed upwards to form new suprabasal layers. In this study, our data show that active nuclear YAP staining of basal keratinocytes temporally correlates with their proliferation dynamics, particularly in the first phase. Moreover, the Notch downstream target HES1 was highly enriched in ∼2% of the basal progenitors at the beginning of the second phase, suggesting that these cells potentially delaminate and migrate suprabasally to continuously supporting epidermal development. In addition, we generated a Krt10-mNeonGreen knockin suprabasal-reporter mouse line and used time-lapse imaging of the developing skin, which identified single cells delaminating and acquiring a suprabasal fate. Based on our data, we propose a working model whereby YAP/TAZ signaling drives proliferation to govern the first phase of epidermal stratification, whereas Notch signaling regulates the second phase through cellular delamination." @default.
- W4309476875 created "2022-11-28" @default.
- W4309476875 creator A5000151284 @default.
- W4309476875 creator A5004582329 @default.
- W4309476875 creator A5014712702 @default.
- W4309476875 creator A5029718206 @default.
- W4309476875 creator A5072342706 @default.
- W4309476875 creator A5006561348 @default.
- W4309476875 date "2022-12-01" @default.
- W4309476875 modified "2023-09-25" @default.
- W4309476875 title "175 Yap and Notch signaling activities correlate with the two phases of skin epidermal stratification during development" @default.
- W4309476875 doi "https://doi.org/10.1016/j.jid.2022.09.186" @default.
- W4309476875 hasPublicationYear "2022" @default.
- W4309476875 type Work @default.
- W4309476875 citedByCount "0" @default.
- W4309476875 crossrefType "journal-article" @default.
- W4309476875 hasAuthorship W4309476875A5000151284 @default.
- W4309476875 hasAuthorship W4309476875A5004582329 @default.
- W4309476875 hasAuthorship W4309476875A5006561348 @default.
- W4309476875 hasAuthorship W4309476875A5014712702 @default.
- W4309476875 hasAuthorship W4309476875A5029718206 @default.
- W4309476875 hasAuthorship W4309476875A5072342706 @default.
- W4309476875 hasBestOaLocation W43094768751 @default.
- W4309476875 hasConcept C104317684 @default.
- W4309476875 hasConcept C105702510 @default.
- W4309476875 hasConcept C161879069 @default.
- W4309476875 hasConcept C163952510 @default.
- W4309476875 hasConcept C201750760 @default.
- W4309476875 hasConcept C2776458125 @default.
- W4309476875 hasConcept C2777074287 @default.
- W4309476875 hasConcept C2777624698 @default.
- W4309476875 hasConcept C2780283210 @default.
- W4309476875 hasConcept C28328180 @default.
- W4309476875 hasConcept C54355233 @default.
- W4309476875 hasConcept C62478195 @default.
- W4309476875 hasConcept C81885089 @default.
- W4309476875 hasConcept C86339819 @default.
- W4309476875 hasConcept C86803240 @default.
- W4309476875 hasConcept C95444343 @default.
- W4309476875 hasConceptScore W4309476875C104317684 @default.
- W4309476875 hasConceptScore W4309476875C105702510 @default.
- W4309476875 hasConceptScore W4309476875C161879069 @default.
- W4309476875 hasConceptScore W4309476875C163952510 @default.
- W4309476875 hasConceptScore W4309476875C201750760 @default.
- W4309476875 hasConceptScore W4309476875C2776458125 @default.
- W4309476875 hasConceptScore W4309476875C2777074287 @default.
- W4309476875 hasConceptScore W4309476875C2777624698 @default.
- W4309476875 hasConceptScore W4309476875C2780283210 @default.
- W4309476875 hasConceptScore W4309476875C28328180 @default.
- W4309476875 hasConceptScore W4309476875C54355233 @default.
- W4309476875 hasConceptScore W4309476875C62478195 @default.
- W4309476875 hasConceptScore W4309476875C81885089 @default.
- W4309476875 hasConceptScore W4309476875C86339819 @default.
- W4309476875 hasConceptScore W4309476875C86803240 @default.
- W4309476875 hasConceptScore W4309476875C95444343 @default.
- W4309476875 hasIssue "12" @default.
- W4309476875 hasLocation W43094768751 @default.
- W4309476875 hasOpenAccess W4309476875 @default.
- W4309476875 hasPrimaryLocation W43094768751 @default.
- W4309476875 hasRelatedWork W1965921323 @default.
- W4309476875 hasRelatedWork W1978215356 @default.
- W4309476875 hasRelatedWork W2003206661 @default.
- W4309476875 hasRelatedWork W2056560678 @default.
- W4309476875 hasRelatedWork W2081394823 @default.
- W4309476875 hasRelatedWork W2085021251 @default.
- W4309476875 hasRelatedWork W2111214065 @default.
- W4309476875 hasRelatedWork W2323039701 @default.
- W4309476875 hasRelatedWork W2801524442 @default.
- W4309476875 hasRelatedWork W4309476875 @default.
- W4309476875 hasVolume "142" @default.
- W4309476875 isParatext "false" @default.
- W4309476875 isRetracted "false" @default.
- W4309476875 workType "article" @default.