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• W4309479548 abstract "ETHNOPHARMACOLOGY RELEVANT: Four Natures and five Flavors comes from the high generalization of medicine pharmacological rules from clinical practice by ancients. Flavor and Naturesare both descriptions of the effect properties of traditional Chinese medicine. At present, researchers have realized that the Flavors (Pungent, Sour, Sweet, Bitter and Salty) are related to the different pharmacological effects of treatment. The Natures (Warm, Hot, Cold and Cool) are closely related to energy and substance metabolism and contribute to the effect of the Flavors. Since Four Natures and five Flavors are the rules derived from clinical practice, how to describe and characterize Natures and Flavors scientifically is still a problem that needs to be solved.the aim is to objectively further understand the scientific connotations of properties (Flavorsand Natures) from the perspective of metabolomics and characterize them by metabolites.Pungent-Neutral, Sweet-Neutral and Bitter-Neutral TCMs were selected to characterize the Flavors (Pungent, Sweet and Bitter). Pungent-Warm and Bitter-Cold were selected to characterize the Natures (Warm and Cold). The rat serum metabolomics was performed on UHPLC-Q-Exactive. Metabolites were identified through the metabolites databases and related literature.The Flavors and Natures metabolites were identified, respectively, including four Pungent, four Sweet and thirteen Bitter characterized metabolites and thirteen Cold and sixteen Warmrelated metabolites.The Natures characterized metabolites show the Natures are closely related to lipid and energy metabolism. The Warm may promote lipid metabolism to produce ATP to generate energy through bile acid metabolism and purine metabolism. The Cold may inhibit lipid metabolism to generate ATP to decrease energy through the way of tryptophan metabolism and purine metabolism. The Flavors characteristic metabolites can provide a theoretical basis for the rules of the Flavors. These metabolites can also be used to characterize TCM's Natures and Flavors in the development of traditional Chinese medicine resources and quality control." @default.
• W4309479548 created "2022-11-28" @default.
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• W4309479548 date "2023-02-01" @default.
• W4309479548 modified "2023-09-26" @default.
• W4309479548 title "UPLC-Q-Exactive-based rats serum metabolomics for characterization of traditional Chinese medicine Natures and Flavors" @default.
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• W4309479548 doi "https://doi.org/10.1016/j.jep.2022.115931" @default.
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