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- W4309479564 abstract "It is empirically known that wounds on the oral mucosa heal faster than those on the skin, and comparative molecular profiling using human subject from oral mucosa and skin tissue has revealed that the transcription factor SOX2, which is highly expressed in the oral mucosa but not in the skin, activates the mucosal epithelium in the steady state, creating an environment conducive to wound healing. Recent study demonstrated that cutaneous wound healing in epidermal specific SOX2-overexpresing mice was promoted compared with control mice. From these results, we hypothesized that SOX2 overexpression in keratinocytes may inhibit the development of ulcer formation caused by cutaneous ischemia-reperfusion (I/R) injury, which is closely related to the pathogenesis of pressure ulcers. The objective was to clarify the role of SOX2 in cutaneous I/R injury and to evaluate the protective effects of SOX2 overexpression in keratinocytes on cutaneous I/R injury. Immunostaining and qPCR analysis showed that SOX2 is transiently expressed in the epidermis after cutaneous I/R injury. The development of ulcer formation was significantly inhibited in SOX2-overexpresing mice. Immunostaining using skin tissue at I/R site revealed that the number of infiltrating inflammatory cells, apoptotic cells, vascular damage, hypoxic areas were significantly suppressed in SOX2-overexpresing mice. mRNA levels of inflammatory cytokines expression such as TNFα and iNOS tended to be reduced in SOX2-overexpresing mice, while the expression of HO-1, an antioxidant stress factor, and the EGF ligands, AREG and HBEGF, were significantly elevated. We observed similar trends in in vitro experiments using keratinocytes extracted from SOX2 transgenic mouse. These findings suggest that HO-1 and EGF ligands produced by SOX2 in keratinocytes may play an important role in regulating cutaneous I/R injury and have potential for therapeutic application in pressure ulcers." @default.
- W4309479564 created "2022-11-28" @default.
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- W4309479564 date "2022-12-01" @default.
- W4309479564 modified "2023-09-27" @default.
- W4309479564 title "601 Overexpression of the transcription factor SOX2 in keratinocytes inhibits pressure ulcer formation after cutaneous I/R injury" @default.
- W4309479564 doi "https://doi.org/10.1016/j.jid.2022.09.618" @default.
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