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- W4309481477 abstract "Non-melanoma skin cancer (NMSC) represents the most frequent type of cancers among Caucasians. Consisting of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), which both develop in the epidermis of the skin. The incidence of NMSC has increased by 33% over the past 10 years. The steadily increasing number of cases continue to cause burden to society and health care. Vitiligo is an autoimmune disease characterized by white depigmented skin lesions due to local loss of melanocytes. We showed the protective effect of vitiligo against melanoma and clinical and epidemiological data suggest that vitiligo may also suppress NMSC. Non-immunological pathways, such as the p53 pathway of which increased expression has been found in vitiligo skin, could be involved in the protection against NMSC. The aim of this study is to explore the potential role of p53 expression in vitiligo skin and its relation to NMSC. Validation of the increased P53 expression in vitiligo skin will be done using lesional and nonlesional biopsies versus healthy skin. Additionally, p53 deregulation in keratinocytes and infiltrating immune cells will be explored using two independent scRNAseq vitiligo datasets and confirmed using immunohistochemistry. Furthermore we will analyze p53 expression in BCCs from a vitiligo patient who developed halo-regions (depigmented regions) around superficial BCCs that partially went into regression, while nodular BCCs without a halo did not. Additionally, we will investigate if p53 expression correlates NMSC regression. Finally we will explore if imiquimod also induces p53 expression in normal skin." @default.
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- W4309481477 date "2022-12-01" @default.
- W4309481477 modified "2023-10-03" @default.
- W4309481477 title "503 Decreased non-melanoma skin cancer prevalence in vitiligo patients: A protective role for the P53 pathway?" @default.
- W4309481477 doi "https://doi.org/10.1016/j.jid.2022.09.517" @default.
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