FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309481545> ?p ?o ?g. }

• W4309481545 endingPage "121201" @default.
• W4309481545 startingPage "121201" @default.
• W4309481545 abstract "Psoriasis is a chronic inflammatory skin disease and lysophosphatidic acid (LPA) has recently been reported to contribute to its pathogenesis through keratinocyte proliferation. In this study, we investigated the metabolic changes in the LPA-induced keratinocyte hyperproliferation and underlying mechanisms. HaCaT or HEKa cells were treated with LPA in the presence or absence of various chemical inhibitors. The glycolysis stress was measured using the Seahorse extracellular flux analyzer. Gene knockdown by siRNA transfection was used to investigate the role of LPAR1, PGAM1, and HIF-1α in LPA-induced metabolic changes. We confirmed the expression of PGAM1 and HIF-1α in imiquimod (IMQ)-induced psoriasis-like BALB/c mice. LPA increased aerobic glycolysis; however, treatment with ki16425, or LPAR1 knockdown inhibited LPA-induced glycolysis in HaCaT cells. LPA increased the expression of glycolytic enzyme PGAM1 through LPAR1. PGAM1 knockdown in HaCaT cells suppressed LPA-induced cell proliferation, changes in cell cycle factor expression, and inhibited LPA-induced aerobic glycolysis. LPA sequentially activated AKT, mTOR, its downstream target, p70 S6K, and increased HIF-1α expression through LPAR1. HIF-1α knockdown inhibited LPA-induced PGAM1 expression and aerobic glycolysis. A6730 also decreased LPA-induced activation of mTOR and p70 S6K and LPA-induced increases in HIF-1α and PGAM1 expression. Ki16425 suppressed the increased expression of PGAM1 and HIF-1α in the lesions of IMQ-induced psoriasis-like mice. In primary keratinocytes, LPA/LPAR1 signaling also induced AKT-mediated aerobic glycolysis. Collectively, the results demonstrated that LPA induces aerobic glycolysis via AKT/mTOR/HIF-1α-dependent PGAM1 expression during keratinocytes proliferation and this might be one of the mechanisms of psoriasis development." @default.
• W4309481545 created "2022-11-28" @default.
• W4309481545 creator A5060181991 @default.
• W4309481545 creator A5060893091 @default.
• W4309481545 creator A5065005770 @default.
• W4309481545 creator A5079139919 @default.
• W4309481545 date "2022-12-01" @default.
• W4309481545 modified "2023-10-14" @default.
• W4309481545 title "LPA/LPAR1 signaling induces PGAM1 expression via AKT/mTOR/HIF-1α pathway and increases aerobic glycolysis, contributing to keratinocyte proliferation" @default.
• W4309481545 cites W1556416740 @default.
• W4309481545 cites W1804602290 @default.
• W4309481545 cites W1867360977 @default.
• W4309481545 cites W1895519966 @default.
• W4309481545 cites W1969870436 @default.
• W4309481545 cites W1972812075 @default.
• W4309481545 cites W1990945827 @default.
• W4309481545 cites W1992372128 @default.
• W4309481545 cites W1994103463 @default.
• W4309481545 cites W2014058353 @default.
• W4309481545 cites W2097259163 @default.
• W4309481545 cites W2108812575 @default.
• W4309481545 cites W2168033189 @default.
• W4309481545 cites W2313372982 @default.
• W4309481545 cites W2621594992 @default.
• W4309481545 cites W2792847810 @default.
• W4309481545 cites W2797770424 @default.
• W4309481545 cites W2900761911 @default.
• W4309481545 cites W2902207260 @default.
• W4309481545 cites W2902241316 @default.
• W4309481545 cites W2904620045 @default.
• W4309481545 cites W2906268083 @default.
• W4309481545 cites W2909006834 @default.
• W4309481545 cites W3010751383 @default.
• W4309481545 cites W3016004654 @default.
• W4309481545 cites W3017148053 @default.
• W4309481545 cites W3044102776 @default.
• W4309481545 cites W3122124144 @default.
• W4309481545 cites W3132651105 @default.
• W4309481545 cites W3152978556 @default.
• W4309481545 cites W3203200085 @default.
• W4309481545 cites W3205956676 @default.
• W4309481545 cites W4210536020 @default.
• W4309481545 cites W4211077900 @default.
• W4309481545 cites W4220764503 @default.
• W4309481545 cites W4229451861 @default.
• W4309481545 cites W4286587120 @default.
• W4309481545 cites W628038580 @default.
• W4309481545 doi "https://doi.org/10.1016/j.lfs.2022.121201" @default.
• W4309481545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36400203" @default.
• W4309481545 hasPublicationYear "2022" @default.
• W4309481545 type Work @default.
• W4309481545 citedByCount "2" @default.
• W4309481545 countsByYear W43094815452023 @default.
• W4309481545 crossrefType "journal-article" @default.
• W4309481545 hasAuthorship W4309481545A5060181991 @default.
• W4309481545 hasAuthorship W4309481545A5060893091 @default.
• W4309481545 hasAuthorship W4309481545A5065005770 @default.
• W4309481545 hasAuthorship W4309481545A5079139919 @default.
• W4309481545 hasBestOaLocation W43094815451 @default.
• W4309481545 hasConcept C118995209 @default.
• W4309481545 hasConcept C170493617 @default.
• W4309481545 hasConcept C173396325 @default.
• W4309481545 hasConcept C185592680 @default.
• W4309481545 hasConcept C190283241 @default.
• W4309481545 hasConcept C20251656 @default.
• W4309481545 hasConcept C202751555 @default.
• W4309481545 hasConcept C2776661833 @default.
• W4309481545 hasConcept C2777074287 @default.
• W4309481545 hasConcept C502942594 @default.
• W4309481545 hasConcept C55493867 @default.
• W4309481545 hasConcept C55885012 @default.
• W4309481545 hasConcept C62112901 @default.
• W4309481545 hasConcept C62231903 @default.
• W4309481545 hasConcept C62478195 @default.
• W4309481545 hasConcept C75217442 @default.
• W4309481545 hasConcept C86554907 @default.
• W4309481545 hasConcept C86803240 @default.
• W4309481545 hasConcept C95444343 @default.
• W4309481545 hasConceptScore W4309481545C118995209 @default.
• W4309481545 hasConceptScore W4309481545C170493617 @default.
• W4309481545 hasConceptScore W4309481545C173396325 @default.
• W4309481545 hasConceptScore W4309481545C185592680 @default.
• W4309481545 hasConceptScore W4309481545C190283241 @default.
• W4309481545 hasConceptScore W4309481545C20251656 @default.
• W4309481545 hasConceptScore W4309481545C202751555 @default.
• W4309481545 hasConceptScore W4309481545C2776661833 @default.
• W4309481545 hasConceptScore W4309481545C2777074287 @default.
• W4309481545 hasConceptScore W4309481545C502942594 @default.
• W4309481545 hasConceptScore W4309481545C55493867 @default.
• W4309481545 hasConceptScore W4309481545C55885012 @default.
• W4309481545 hasConceptScore W4309481545C62112901 @default.
• W4309481545 hasConceptScore W4309481545C62231903 @default.
• W4309481545 hasConceptScore W4309481545C62478195 @default.
• W4309481545 hasConceptScore W4309481545C75217442 @default.
• W4309481545 hasConceptScore W4309481545C86554907 @default.
• W4309481545 hasConceptScore W4309481545C86803240 @default.
• W4309481545 hasConceptScore W4309481545C95444343 @default.
• W4309481545 hasFunder F4320321408 @default.

• next