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• W4309484772 endingPage "104590" @default.
• W4309484772 startingPage "104590" @default.
• W4309484772 abstract "Intraepithelial T lymphocytes (T-IELs) are T cells located within the epithelium that provide a critical line of immune defense in the intestinal tract. In pigs, T-IEL abundances and phenotypes are used to infer putative T-IEL functions and vary by intestinal location and age, though investigations regarding porcine T-IELs are relatively limited. In this study, we expand on analyses of porcine intestinal T-IELs to include additional phenotypic designations not previously recognized in pigs. We describe non-conventional CD8α+CD8β− αβ T-IELs that were most prevalent in the distal intestinal tract and primarily CD16+CD27−, a phenotype suggestive of innate-like activation and an activated cell state. Additional T-IEL populations included CD8α+CD8β+ αβ, CD2+CD8α+ γδ, and CD2+CD8α− γδ T-IELs, with increasing proportions of CD16+CD27− phenotype in the distal intestine. Thus, putative non-conventional, activated T-IELs were most abundant in the distal intestine within multiple γδ and αβ T-IEL populations. A comparison of T-IEL and respective mucosal microbial community structures across jejunum, ileum, and cecum of 5- and 7-week-old pigs revealed largest community differences were tissue-dependent for both T-IELs and the microbiota. Between 5 and 7 weeks of age, the largest shifts in microbial community compositions occurred in the large intestine, while the largest shifts in T-IEL communities were in the small intestine. Therefore, results indicate different rates of community maturation and stabilization for porcine T-IELs and the mucosal microbiota for proximal versus distal intestinal locations between 5 and 7 weeks of age. Collectively, data emphasize the intestinal tract as a site of location- and age-specific T-IEL and microbial communities that have important implications for understanding intestinal health in pigs." @default.
• W4309484772 created "2022-11-28" @default.
• W4309484772 creator A5003015899 @default.
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• W4309484772 creator A5045187716 @default.
• W4309484772 creator A5049049507 @default.
• W4309484772 date "2023-02-01" @default.
• W4309484772 modified "2023-10-15" @default.
• W4309484772 title "Intestinal location- and age-specific variation of intraepithelial T lymphocytes and mucosal microbiota in pigs" @default.
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• W4309484772 doi "https://doi.org/10.1016/j.dci.2022.104590" @default.
• W4309484772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36410569" @default.
• W4309484772 hasPublicationYear "2023" @default.

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