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• W4309485768 abstract "To investigate the role and possible molecular mechanism of Schisandrin B-induced cell autophagy in the prevention and treatment of APAP-induced liver injury.Molecular docking method was used to predict the interaction between Schisandrin B and the EGFR protein. HepG2 cells were treated with different concentrations of Schisandrin B for 24 h. Schisandrin B-induced autophagy of HepG2 cells was determined using real-time label-free cell analysis (RTCA), flow cytometry, immunofluorescence, PCR, and western blot. Flow cytometry and western blot were used to explore whether Schisandrin B-induced autophagy plays a role in the prevention and treatment of liver injury via the EGFR/TFEB signaling pathway.Schisandrin B treatment of APAP-induced HepG2 cells inhibited the production of TNF-α and IL-1β. Further, Schisandrin B downregulated EGFR protein expression and activated the EGFR/TFEB signaling pathway. Autophagy inhibition promoted APAP-induced apoptosis of HepG2 cells. Moreover, the protein expression levels of TFEB, LC3 and Beclin-1 were upregulated, whereas those of ATG3 and EGFR were downregulated.Schisandrin B can induce autophagy in HepG2 cells. Autophagy may play a role in the prevention and treatment of liver injury via the EGFR/TFEB signaling pathway. Activation of autophagy enhances the effect of Schisandrin B on APAP-induced liver injury." @default.
• W4309485768 created "2022-11-28" @default.
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• W4309485768 date "2023-01-01" @default.
• W4309485768 modified "2023-09-27" @default.
• W4309485768 title "Schisandrin B ameliorates acute liver injury by regulating EGFR-mediated activation of autophagy" @default.
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• W4309485768 doi "https://doi.org/10.1016/j.bioorg.2022.106272" @default.
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