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- W4309486532 abstract "The pharmaceutical industry has shown a strong interest in flow synthesis and continuous production. In general, solvent selection is performed based on solubility and reactivity/selectivity, but in heterogeneous reactions, solvent properties related to mass transfer can affect the reaction performance. This work presents a model-based analysis of the impact of solvent selection in batch and flow syntheses for heterogeneous hydrogenation, e.g., for doripenem, a commercialized antibiotic. Simulations of reaction conversions under different conditions were conducted. First, a sensitivity analysis was performed, where the effects of individual solvent properties (viscosity, density, Henry’s law constant, and concentration) were examined, followed by solvent selection from six existing candidates. The sensitivity analysis results showed that the individual properties had different impacts on reactions in batch and flow syntheses, and thus the optimal solvent choice varied in each case. The results can be useful for solvent design, such as computer-aided molecular design. A guideline for solvent selection was proposed to assist in reducing dedicated experimental burden and allowing for more deliberate and selective solvent selection." @default.
- W4309486532 created "2022-11-28" @default.
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- W4309486532 date "2023-01-01" @default.
- W4309486532 modified "2023-10-01" @default.
- W4309486532 title "Impact of solvent selection on batch and flow syntheses for heterogeneous hydrogenation in drug substance manufacturing: A model-based analysis" @default.
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- W4309486532 doi "https://doi.org/10.1016/j.cherd.2022.11.012" @default.
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