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• W4309487576 abstract "Cancer is a complex disease caused by genetic and epigenetic alterations in the control of cell division. Findings from the field of cancer genomics and epigenomics have increased our understanding of the origin and evolution of tumorigenic processes, greatly advancing our knowledge of the molecular etiology of cancer. Consequently, any contemporary view of cancer research must consider tumorigenesis as a cellular phenomenon that is a result of the interplay between genetic and epigenetic mutations and their interaction with environmental factors, including our microbiome, that influences cellular metabolism and proliferation rates. The integration and better knowledge of these processes will help us to improve diagnosis, prognosis, and future genetic and epigenetic therapies. Here, I present an overview of the epigenetic processes that are affected in cancer and how they contribute to the onset and progression of the disease. Finally, I discuss how the development of sophisticated experimental approaches and computational tools, including novel ways to exploit large data sets, could contribute to the better understanding and treatment of cancer." @default.
• W4309487576 created "2022-11-28" @default.
• W4309487576 creator A5074558781 @default.
• W4309487576 date "2022-12-01" @default.
• W4309487576 modified "2023-10-10" @default.
• W4309487576 title "Cancer Epigenetics: An Overview" @default.
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• W4309487576 doi "https://doi.org/10.1016/j.arcmed.2022.11.003" @default.
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