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- W4309489066 abstract "Background: We designed this study to determine the false negative rate (FNR), negative predictive value (PPV) and the factors predicting false negativity of pre-treatment axillary ultrasound (AUS). Materials & methods: We retrospectively selected patients with normal lymph nodes on ultrasound, T1, T2 or T3 tumors, invasive cancer, who underwent sentinel lymph node biopsy (SLNB), between January 2019 and December 2020 at Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan. Ultrasound findings were compared with the SLNB results, dividing our study population into False Negative (FN) and True Negative (TN) groups. Clinical, radiological, histopathological parameters and therapeutic strategies were compared between the two groups. Results: Out of 781 patients, 627 (80.2%) had TN, while 154 (19.7%) had FN ultrasound results, with NPV of 80.2%. On univariate analysis, initial tumor size, histopathology, tumor grade, receptors, timing of chemotherapy, and type of surgery were found to have statistically significant difference between the FN and TN AUS groups. On multivariate analysis, tumor size, grade, Progesterone receptor, and human epidermal growth factor receptor 2 (HER 2 neu) status were found to be the significant predicting factors for FN AUS results. Larger, high grade, PR negative and HER 2 neu positive tumors were found to be associated with lower FNR on AUS. Conclusion: Axillary ultrasound is effective in ruling out axillary nodal disease especially in patients with high burden axillary disease, aggressive tumor biology, larger tumor size and higher grade. However, we should be especially cautious while interpreting the results of AUS in case of lobular histology. No conflict of interest." @default.
- W4309489066 created "2022-11-28" @default.
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- W4309489066 date "2022-11-01" @default.
- W4309489066 modified "2023-09-29" @default.
- W4309489066 title "Efficacy of pre-operative axillary ultrasonography in excluding nodal disease – can it replace sentinel lymph node biopsy in early stage breast cancer?" @default.
- W4309489066 doi "https://doi.org/10.1016/s0959-8049(22)01418-6" @default.
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