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- W4309491279 endingPage "901" @default.
- W4309491279 startingPage "883" @default.
- W4309491279 abstract "CD4+ and CD8+ T lymphocytes mediate most of the adaptive immune response against tumors. Naïve T lymphocytes specific for tumor antigens are primed in lymph nodes by dendritic cells. Upon activation, antigen-specific T cells proliferate and differentiate into effector cells that migrate out of peripheral blood into tumor sites in an attempt to eliminate cancer cells. After accomplishing their function, most effector T cells die in the tissue, while a small fraction of antigen-specific T cells persist as long-lived memory cells, circulating between peripheral blood and lymphoid tissues, to generate enhanced immune responses when re-encountering the same antigen. A subset of memory T cells, called resident memory T (TRM) cells, stably resides in non-lymphoid peripheral tissues and may provide rapid immunity independently of T cells recruited from blood. Being adapted to the tissue microenvironment, TRM cells are potentially endowed with the best features to protect against the reemergence of cancer cells. However, when tumors give clinical manifestation, it means that tumor cells have evaded immune surveillance, including that of TRM cells. Here, we review the current knowledge as to how TRM cells are generated during an immune response and then maintained in non-lymphoid tissues. We then focus on what is known about the role of CD4+ and CD8+ TRM cells in antitumor immunity and their possible contribution to the efficacy of immunotherapy. Finally, we highlight some open questions in the field and discuss how new technologies may help in addressing them." @default.
- W4309491279 created "2022-11-28" @default.
- W4309491279 creator A5036094763 @default.
- W4309491279 creator A5078733803 @default.
- W4309491279 date "2022-11-01" @default.
- W4309491279 modified "2023-10-15" @default.
- W4309491279 title "Human T lymphocytes at tumor sites" @default.
- W4309491279 cites W1502260800 @default.
- W4309491279 cites W1537188001 @default.
- W4309491279 cites W1573720570 @default.
- W4309491279 cites W1610017743 @default.
- W4309491279 cites W1875741133 @default.
- W4309491279 cites W1895620535 @default.
- W4309491279 cites W1915043848 @default.
- W4309491279 cites W1966768211 @default.
- W4309491279 cites W1967802627 @default.
- W4309491279 cites W1967994686 @default.
- W4309491279 cites W1971079822 @default.
- W4309491279 cites W1975164490 @default.
- W4309491279 cites W1981480494 @default.
- W4309491279 cites W1986626127 @default.
- W4309491279 cites W1990273429 @default.
- W4309491279 cites W1992349538 @default.
- W4309491279 cites W1994838458 @default.
- W4309491279 cites W2004880863 @default.
- W4309491279 cites W2006192795 @default.
- W4309491279 cites W2007223760 @default.
- W4309491279 cites W2010011171 @default.
- W4309491279 cites W2013479589 @default.
- W4309491279 cites W2021472146 @default.
- W4309491279 cites W2021750859 @default.
- W4309491279 cites W2030378290 @default.
- W4309491279 cites W2031551895 @default.
- W4309491279 cites W2033505817 @default.
- W4309491279 cites W2044560758 @default.
- W4309491279 cites W2046731919 @default.
- W4309491279 cites W2050407789 @default.
- W4309491279 cites W2052275203 @default.
- W4309491279 cites W2057609434 @default.
- W4309491279 cites W2061140050 @default.
- W4309491279 cites W2068149369 @default.
- W4309491279 cites W2070570719 @default.
- W4309491279 cites W2074161152 @default.
- W4309491279 cites W2081097093 @default.
- W4309491279 cites W2082595913 @default.
- W4309491279 cites W2085875957 @default.
- W4309491279 cites W2100609582 @default.
- W4309491279 cites W2103119361 @default.
- W4309491279 cites W2113628320 @default.
- W4309491279 cites W2117437045 @default.
- W4309491279 cites W2127723151 @default.
- W4309491279 cites W2129045181 @default.
- W4309491279 cites W2131014265 @default.
- W4309491279 cites W2131107006 @default.
- W4309491279 cites W2132644211 @default.
- W4309491279 cites W2136349962 @default.
- W4309491279 cites W2137327945 @default.
- W4309491279 cites W2140368190 @default.
- W4309491279 cites W2145164692 @default.
- W4309491279 cites W2145958269 @default.
- W4309491279 cites W2148360952 @default.
- W4309491279 cites W2148737454 @default.
- W4309491279 cites W2150096946 @default.
- W4309491279 cites W2151322257 @default.
- W4309491279 cites W2156375860 @default.
- W4309491279 cites W2161689282 @default.
- W4309491279 cites W2165229668 @default.
- W4309491279 cites W2166321278 @default.
- W4309491279 cites W2168663010 @default.
- W4309491279 cites W2170904230 @default.
- W4309491279 cites W2201837705 @default.
- W4309491279 cites W2215044127 @default.
- W4309491279 cites W2266090185 @default.
- W4309491279 cites W2273021913 @default.
- W4309491279 cites W2282456285 @default.
- W4309491279 cites W2317145780 @default.
- W4309491279 cites W2334798192 @default.
- W4309491279 cites W2336322268 @default.
- W4309491279 cites W2337944657 @default.
- W4309491279 cites W2378290597 @default.
- W4309491279 cites W2405078719 @default.
- W4309491279 cites W2473001391 @default.
- W4309491279 cites W2517078013 @default.
- W4309491279 cites W2519636301 @default.
- W4309491279 cites W2530067632 @default.
- W4309491279 cites W2533830780 @default.
- W4309491279 cites W2550291749 @default.
- W4309491279 cites W2552653135 @default.
- W4309491279 cites W2564961580 @default.
- W4309491279 cites W2566205732 @default.
- W4309491279 cites W2576923352 @default.
- W4309491279 cites W2588304745 @default.
- W4309491279 cites W2589066097 @default.
- W4309491279 cites W2599601523 @default.
- W4309491279 cites W2605621988 @default.
- W4309491279 cites W2607079475 @default.
- W4309491279 cites W2610932550 @default.
- W4309491279 cites W2611694282 @default.