FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309495375> ?p ?o ?g. }

• W4309495375 abstract "Background: The endocannabinoid (eCB) system plays an important role in homeostatic regulation of anxiety and stress responses; however, the eCB system can be disrupted following traumatic stressors. Additionally, traumatic or chronic stressors that occur during adulthood or early life can cause long-lasting disturbances in the eCB system. These alterations interfere with hypothalamic-pituitary-adrenal axis function and may be involved in lifelong increased fear and anxiety behaviors as well as increased risk for development of post-traumatic stress disorder (PTSD). Methods: This review focuses on the implications of trauma and significant stressors on eCB functionality and neural pathways, both in adolescence and into adulthood, as well as the current state of testing for CBD efficacy in treating pediatric and adult patients suffering from stress-induced eCB dysregulation. Articles were searched via Pubmed and included studies examining eCB modulation of stress-related disorders in both clinical settings and preclinical models. Conclusion: Given the potential for lifelong alterations in eCB signaling that can mediate stress responsiveness, consideration of pharmaceutical or nutraceutical agents that impact eCB targets may improve clinical outcomes in stress-related disorders. However, caution may be warranted in utilization of medicinal cannabinoid products that contain delta-9-tetrahydrocannabinol due to pronounced euphorigenic effects and potential to exacerbate stress-related behaviors. Other cannabinoid products, such as cannabidiol (CBD), have shown promise in reducing stress-related behaviors in pre-clinical models. Overall, pre-clinical evidence supports CBD as a potential treatment for stress or anxiety disorders resulting from previously stressful events, particularly by reducing fearful behavior and promoting extinction of contextual fear memories, which are hallmarks of PTSD. However, very limited clinical research has been conducted examining the potential effectiveness of CBD in this regard and should be examined further." @default.
• W4309495375 created "2022-11-28" @default.
• W4309495375 creator A5013765724 @default.
• W4309495375 creator A5040978673 @default.
• W4309495375 creator A5091103521 @default.
• W4309495375 date "2022-11-21" @default.
• W4309495375 modified "2023-09-28" @default.
• W4309495375 title "Potential Utility of Cannabidiol in Stress-Related Disorders" @default.
• W4309495375 cites W1204416926 @default.
• W4309495375 cites W1495976759 @default.
• W4309495375 cites W1521382255 @default.
• W4309495375 cites W1547358456 @default.
• W4309495375 cites W1763274674 @default.
• W4309495375 cites W1836729582 @default.
• W4309495375 cites W1966133745 @default.
• W4309495375 cites W1966656140 @default.
• W4309495375 cites W1969415886 @default.
• W4309495375 cites W1969925342 @default.
• W4309495375 cites W1973905367 @default.
• W4309495375 cites W1979620819 @default.
• W4309495375 cites W1984675094 @default.
• W4309495375 cites W1997302824 @default.
• W4309495375 cites W1997987765 @default.
• W4309495375 cites W2003968300 @default.
• W4309495375 cites W2008565294 @default.
• W4309495375 cites W2008780699 @default.
• W4309495375 cites W2009594014 @default.
• W4309495375 cites W2010649745 @default.
• W4309495375 cites W2011904866 @default.
• W4309495375 cites W2012483271 @default.
• W4309495375 cites W2017255572 @default.
• W4309495375 cites W2018532397 @default.
• W4309495375 cites W2022676940 @default.
• W4309495375 cites W2023110774 @default.
• W4309495375 cites W2024165298 @default.
• W4309495375 cites W2024564598 @default.
• W4309495375 cites W2024653583 @default.
• W4309495375 cites W2024985387 @default.
• W4309495375 cites W2027206234 @default.
• W4309495375 cites W2029228061 @default.
• W4309495375 cites W2030623240 @default.
• W4309495375 cites W2031674889 @default.
• W4309495375 cites W2036547523 @default.
• W4309495375 cites W2036824041 @default.
• W4309495375 cites W2040268671 @default.
• W4309495375 cites W2043345871 @default.
• W4309495375 cites W2043545748 @default.
• W4309495375 cites W2044573242 @default.
• W4309495375 cites W2048249572 @default.
• W4309495375 cites W2049641826 @default.
• W4309495375 cites W2051715358 @default.
• W4309495375 cites W2064543190 @default.
• W4309495375 cites W2067487104 @default.
• W4309495375 cites W2068657595 @default.
• W4309495375 cites W2071372675 @default.
• W4309495375 cites W2072442611 @default.
• W4309495375 cites W2074290211 @default.
• W4309495375 cites W2085741941 @default.
• W4309495375 cites W2088520957 @default.
• W4309495375 cites W2091726345 @default.
• W4309495375 cites W2094393564 @default.
• W4309495375 cites W2095036452 @default.
• W4309495375 cites W2100987960 @default.
• W4309495375 cites W2110064169 @default.
• W4309495375 cites W2116042849 @default.
• W4309495375 cites W2119071913 @default.
• W4309495375 cites W2120230768 @default.
• W4309495375 cites W2122201859 @default.
• W4309495375 cites W2122370310 @default.
• W4309495375 cites W2123054908 @default.
• W4309495375 cites W2123198963 @default.
• W4309495375 cites W2128312680 @default.
• W4309495375 cites W2130587723 @default.
• W4309495375 cites W2135985648 @default.
• W4309495375 cites W2136557533 @default.
• W4309495375 cites W2150840196 @default.
• W4309495375 cites W2157098008 @default.
• W4309495375 cites W2165346195 @default.
• W4309495375 cites W2169449092 @default.
• W4309495375 cites W2169990926 @default.
• W4309495375 cites W2170672468 @default.
• W4309495375 cites W2174548557 @default.
• W4309495375 cites W2229642957 @default.
• W4309495375 cites W2263649385 @default.
• W4309495375 cites W2268947375 @default.
• W4309495375 cites W2344705609 @default.
• W4309495375 cites W2345821480 @default.
• W4309495375 cites W2395642679 @default.
• W4309495375 cites W2427182478 @default.
• W4309495375 cites W2509570652 @default.
• W4309495375 cites W2519605175 @default.
• W4309495375 cites W2531890306 @default.
• W4309495375 cites W2767817531 @default.
• W4309495375 cites W2790126944 @default.
• W4309495375 cites W2791686089 @default.
• W4309495375 cites W2796803789 @default.
• W4309495375 cites W2804921146 @default.
• W4309495375 cites W2805268326 @default.
• W4309495375 cites W2888814179 @default.
• W4309495375 cites W2898687486 @default.

• next