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• W4309496796 abstract "Abstract Background Currently, alternative medical imaging methods for the assessment of pulmonary involvement in patients infected with COVID-19 are sought that combine a higher sensitivity than conventional (attenuation-based) chest radiography with a lower radiation dose than CT imaging. Methods Sixty patients with COVID-19-associated lung changes in a CT scan and 40 subjects without pathologic lung changes visible in the CT scan were included (in total, 100, 59 male, mean age 58 ± 14 years). All patients gave written informed consent. We employed a clinical setup for grating-based dark-field chest radiography, obtaining both a dark-field and a conventional attenuation image in one image acquisition. Attenuation images alone, dark-field images alone, and both displayed simultaneously were assessed for the presence of COVID-19-associated lung changes on a scale from 1 to 6 (1 = surely not, 6 = surely) by four blinded radiologists. Statistical analysis was performed by evaluation of the area under the receiver–operator-characteristics curves (AUC) using Obuchowski’s method with a 0.05 level of significance. Results We show that dark-field imaging has a higher sensitivity for COVID-19-pneumonia than attenuation-based imaging and that the combination of both is superior to one imaging modality alone. Furthermore, a quantitative image analysis shows a significant reduction of dark-field signals for COVID-19-patients. Conclusions Dark-field imaging complements and improves conventional radiography for the visualisation and detection of COVID-19-pneumonia." @default.
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• W4309496796 date "2022-11-21" @default.
• W4309496796 modified "2023-10-09" @default.
• W4309496796 title "Dark-field chest X-ray imaging for the assessment of COVID-19-pneumonia" @default.
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• W4309496796 doi "https://doi.org/10.1038/s43856-022-00215-3" @default.
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