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• W4309497280 abstract "An animal model that fully recapitulates severe COVID-19 presentation in humans has been a top priority since the discovery of SARS-CoV-2 in 2019. Although multiple animal models are available for mild to moderate clinical disease, models that develop severe disease are still needed. Mink experimentally infected with SARS-CoV-2 developed severe acute respiratory disease, as evident by clinical respiratory disease, radiological, and histological changes. Virus was detected in nasal, oral, rectal, and fur swabs. Deep sequencing of SARS-CoV-2 from oral swabs and lung tissue samples showed repeated enrichment for a mutation in the gene encoding nonstructural protein 6 in open reading frame 1ab. Together, these data indicate that American mink develop clinical features characteristic of severe COVID-19 and, as such, are uniquely suited to test viral countermeasures." @default.
• W4309497280 created "2022-11-28" @default.
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• W4309497280 date "2022-11-22" @default.
• W4309497280 modified "2023-10-10" @default.
• W4309497280 title "Severe acute respiratory disease in American mink experimentally infected with SARS-CoV-2" @default.
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• W4309497280 doi "https://doi.org/10.1172/jci.insight.159573" @default.
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