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- W4309501834 abstract "Abstract Human Respiratory Syncytial Virus (HRSV) is one of the most prevalent respiratory viral pathogens among infants and toddlers under the age of two and the elderly. Two of eleven proteins of HRSV, non-structural proteins, NS1 and NS2, are not present in the viral particle but are the first to be translated during virus replication. Previous findings indicate a significant impact of NS proteins on the host immune response. Both NS proteins are linked with interferon signaling interference, efficiently blocking IFN-associated gene transcription and T-cell maturation by association with key proteins on the IFN-signaling pathway. Here, we demonstrated that viral non-structural proteins genes themselves cause differential expression of a number of human host genes, including those of cytokines (TNF-α, IL-6), a component of AP-1 transcription factor (FOSB), and long non-coding RNAs (MALAT1 and RP11-510N19.5). Thus, our results imply that NS proteins' impact goes beyond IFN-I signaling pathways and further into immune response regulation, especially in the case of lncRNA. It also provides new data on HRSV and host cell interplay and exposes viable and previously undiscussed ways of viral interference with the host immune system." @default.
- W4309501834 created "2022-11-28" @default.
- W4309501834 creator A5050468944 @default.
- W4309501834 creator A5054394334 @default.
- W4309501834 creator A5080934662 @default.
- W4309501834 date "2022-11-21" @default.
- W4309501834 modified "2023-09-24" @default.
- W4309501834 title "IL-6, TNF-α genes, and long non-coding RNAs are targets for non-structural proteins NS1 and NS2 of Human Respiratory Syncytial Virus" @default.
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- W4309501834 doi "https://doi.org/10.21203/rs.3.rs-2280280/v1" @default.
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