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- W4309504564 abstract "Abstract FcμR is the IgM-specific Fc receptor involved in the survival and activation of B cells. Using cryo-EM, we reveal eight binding sites for the human FcμR Ig domain on the IgM pentamer, one of which overlaps with the receptor binding site for the transcytosis receptor pIgR, but a different mode of binding explains Ig isotype specificity. The complex explains engagement with polymeric serum IgM and the monomeric IgM B cell receptor." @default.
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- W4309504564 date "2022-11-18" @default.
- W4309504564 modified "2023-10-16" @default.
- W4309504564 title "Structural basis for Fc receptor recognition of immunoglobulin M" @default.
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- W4309504564 doi "https://doi.org/10.1101/2022.11.18.517032" @default.
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