FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309506516> ?p ?o ?g. }

• W4309506516 endingPage "670" @default.
• W4309506516 startingPage "657" @default.
• W4309506516 abstract "The aim was to investigate the association between plasma levels of cellular adhesion molecules (CAMs) and risk factors, subtypes, severity and short-term mortality of acute ischemic stroke (IS), and to identify a panel of biomarkers to predict short-term mortality after IS. The prospective study evaluated 132 IS patients within 24 h of their hospital admission. The baseline IS severity was assessed using the National Institutes Health Stroke Scale (NIHSS) and categorized as mild (NIHSS < 5), moderate (NIHSS 5–14) and severe (NIHSS ≥ 15). After three-month follow-up, the disability was assessed using the modified Rankin Scale (mRS); moreover, the patients were classified as survivors and non-survivors. Baseline inflammatory and anti-inflammatory cytokines and soluble CAMs were evaluated. Twenty-nine (21.9%) IS patients were non-survivors and showed higher NIHSS and soluble vascular cellular adhesion molecule 1 (sVCAM-1) than the survivors. The sVCAM-1 levels positively correlated with age, homocysteine, severity, and disability. The model #3 combining sVCAM-1 and NIHSS showed better results to predict short-term mortality with an area under the curve receiving operating characteristics (AUC/ROC) of 0.8841 [95% confidence interval (CI): 0.795–0.941] than the models with sVCAM-1 and NIHSS alone, with positive predictive value of 68.0%, negative predictive value of 91.3%, and accuracy of 86.5%. In conclusion, the combined model with baseline severity of IS and sVCAM-1 levels can early predict the prognosis of IS patients who may benefit with therapeutic measures of personalized therapy that taken into account these biomarkers. Moreover, this result suggests that VCAM-1 might be a potential target for the therapeutic strategies in IS." @default.
• W4309506516 created "2022-11-28" @default.
• W4309506516 creator A5006158088 @default.
• W4309506516 creator A5009965184 @default.
• W4309506516 creator A5010240103 @default.
• W4309506516 creator A5017735421 @default.
• W4309506516 creator A5030777834 @default.
• W4309506516 creator A5042829268 @default.
• W4309506516 creator A5050405340 @default.
• W4309506516 creator A5063873839 @default.
• W4309506516 creator A5083045220 @default.
• W4309506516 date "2022-11-21" @default.
• W4309506516 modified "2023-10-14" @default.
• W4309506516 title "Baseline severity and soluble vascular cell adhesion molecule 1 (sVCAM-1) as biomarker predictors of short-term mortality in acute ischemic stroke" @default.
• W4309506516 cites W1579413437 @default.
• W4309506516 cites W1588197618 @default.
• W4309506516 cites W1843396156 @default.
• W4309506516 cites W1898402776 @default.
• W4309506516 cites W1966352792 @default.
• W4309506516 cites W1972468874 @default.
• W4309506516 cites W1984182546 @default.
• W4309506516 cites W1984829261 @default.
• W4309506516 cites W1991084866 @default.
• W4309506516 cites W1991874921 @default.
• W4309506516 cites W1992467615 @default.
• W4309506516 cites W1994033703 @default.
• W4309506516 cites W1996751718 @default.
• W4309506516 cites W1998641623 @default.
• W4309506516 cites W2027264108 @default.
• W4309506516 cites W2033844247 @default.
• W4309506516 cites W2034269870 @default.
• W4309506516 cites W2037954427 @default.
• W4309506516 cites W2041182922 @default.
• W4309506516 cites W2046885658 @default.
• W4309506516 cites W2055785462 @default.
• W4309506516 cites W2060537441 @default.
• W4309506516 cites W2069790789 @default.
• W4309506516 cites W2077321915 @default.
• W4309506516 cites W2080504768 @default.
• W4309506516 cites W2083653379 @default.
• W4309506516 cites W2088875229 @default.
• W4309506516 cites W2099508693 @default.
• W4309506516 cites W2103285088 @default.
• W4309506516 cites W2109786102 @default.
• W4309506516 cites W2114806898 @default.
• W4309506516 cites W2119360937 @default.
• W4309506516 cites W2126125759 @default.
• W4309506516 cites W2131664005 @default.
• W4309506516 cites W2135410853 @default.
• W4309506516 cites W2136030857 @default.
• W4309506516 cites W2138595885 @default.
• W4309506516 cites W2141683458 @default.
• W4309506516 cites W2161245729 @default.
• W4309506516 cites W2167620371 @default.
• W4309506516 cites W2330248884 @default.
• W4309506516 cites W2587953391 @default.
• W4309506516 cites W2796284997 @default.
• W4309506516 cites W2886742436 @default.
• W4309506516 cites W2895166781 @default.
• W4309506516 cites W2899197889 @default.
• W4309506516 cites W2922001972 @default.
• W4309506516 cites W3006514501 @default.
• W4309506516 cites W3012684581 @default.
• W4309506516 cites W3037542909 @default.
• W4309506516 cites W3043509097 @default.
• W4309506516 cites W3096382236 @default.
• W4309506516 cites W3099521484 @default.
• W4309506516 cites W3120917678 @default.
• W4309506516 cites W3127576695 @default.
• W4309506516 cites W3159565898 @default.
• W4309506516 cites W3169331568 @default.
• W4309506516 cites W3170663387 @default.
• W4309506516 cites W3190980900 @default.
• W4309506516 cites W3197233575 @default.
• W4309506516 cites W3212842713 @default.
• W4309506516 cites W4230870013 @default.
• W4309506516 doi "https://doi.org/10.1007/s11011-022-01116-z" @default.
• W4309506516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36409382" @default.
• W4309506516 hasPublicationYear "2022" @default.
• W4309506516 type Work @default.
• W4309506516 citedByCount "1" @default.
• W4309506516 countsByYear W43095065162023 @default.
• W4309506516 crossrefType "journal-article" @default.
• W4309506516 hasAuthorship W4309506516A5006158088 @default.
• W4309506516 hasAuthorship W4309506516A5009965184 @default.
• W4309506516 hasAuthorship W4309506516A5010240103 @default.
• W4309506516 hasAuthorship W4309506516A5017735421 @default.
• W4309506516 hasAuthorship W4309506516A5030777834 @default.
• W4309506516 hasAuthorship W4309506516A5042829268 @default.
• W4309506516 hasAuthorship W4309506516A5050405340 @default.
• W4309506516 hasAuthorship W4309506516A5063873839 @default.
• W4309506516 hasAuthorship W4309506516A5083045220 @default.
• W4309506516 hasBestOaLocation W43095065162 @default.
• W4309506516 hasConcept C118552586 @default.
• W4309506516 hasConcept C126322002 @default.
• W4309506516 hasConcept C127413603 @default.
• W4309506516 hasConcept C164705383 @default.
• W4309506516 hasConcept C16568411 @default.

• next