Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309508568> ?p ?o ?g. }
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- W4309508568 abstract "Self-emulsifying drug delivery systems (SEDDS) are formulations consisting of oil phase, emulsifiers, and co-emulsifiers, which can be spontaneously emulsified in the body to form O/W microemulsion. Traditionally, SEDDS are used commercially for the improvement of oral absorption and in vivo performances for poorly water-soluble drugs. However, SEDDS formulations were rarely reported for the delivery of water-soluble drugs. Recent studies have found that SEDDS have the potential for water-soluble macromolecular drugs by the application of the hydrophobic ion pairing (HIP) technology.This review summarized the characteristics of HIP complexes in SEDDS and introduced their advantages and discussed the future prospects of HIP-based SEDDS in drug delivery.Hydrophobic ion pairing (HIP) is a technology that combines lipophilic structures on polar counterions to increase the lipophilicity through electrostatic interaction. Recent studies showed that HIP-based SEDDS offer an effective way to increase the mucosal permeability and improve the chemical stability for antibiotics, proteases, DNA-based drugs, and other water-soluble macromolecular drugs. It is believed that HIP-based SEDDS offer a potential and attractive method capable of delivering hydrophilic macromolecules with ionizable groups for oral administration." @default.
- W4309508568 created "2022-11-28" @default.
- W4309508568 creator A5006295324 @default.
- W4309508568 creator A5008776742 @default.
- W4309508568 creator A5027578647 @default.
- W4309508568 creator A5029631182 @default.
- W4309508568 creator A5035456549 @default.
- W4309508568 creator A5051644109 @default.
- W4309508568 creator A5064323494 @default.
- W4309508568 creator A5080732215 @default.
- W4309508568 creator A5090313948 @default.
- W4309508568 date "2023-01-01" @default.
- W4309508568 modified "2023-10-16" @default.
- W4309508568 title "Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs." @default.
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