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• W4309509750 abstract "The present study aims to analyze the impact of PRO 160/120 prescriptions on the incidence of urinary incontinence, polyuria (including nocturia), urinary retention, and erectile dysfunction in a real-world setting in Germany and to compare these data with data for the 5-ARIs finasteride and dutasteride, and the α1-adrenoceptor antagonists tamsulosin and tamsulosin/dutasteride fixed-dose combination. This retrospective study was based on the IQVIA Disease Analyzer database and included male patients with an initial prescription of PRO 160/120, finasteride, dutasteride, tamsulosin, or tamsulosin/dutasteride fixed-dose combination between January 2010 and September 2020. Multivariable logistic regression analyses adjusted for age, health insurance, specialty, and relevant co-diagnoses were performed to estimate the association between PRO 160/120 prescriptions and incidence of pre-defined outcomes. A total of 77,923 patients were included in the study, 3,035 of whom received PRO 160/120. PRO 160/120 was significantly associated with reduced incidence of urinary incontinence (OR: 1.48; 95% CI: 1.10–1.98) and urinary retention compared to tamsulosin (OR: 3.39; 95% CI: 1.75–6.57 and tamsulosin/dutasteride (OR: 2.81; 95% CI: 1.35–5.82). Furthermore, PRO 160/120 significantly reduced the incidence of erectile dysfunction compared to dutasteride (OR: 2.79; 95% CI: 1.49–5.25). At the same time, patients receiving PRO 160/120 showed the same incidence of the remaining complications as those taking the reference substances. In conclusion, we observed a significant association between PRO 160/120 prescription and reduced incidence of urinary incontinence and urinary retention compared to tamsulosin and tamsulosin/dutasteride, as well as reduced incidence of erectile dysfunction compared to dutasteride." @default.
• W4309509750 created "2022-11-28" @default.
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• W4309509750 date "2022-11-21" @default.
• W4309509750 modified "2023-10-05" @default.
• W4309509750 title "Association between <i>PRO 160/120</i> prescriptions and incidence of benign prostatic hyperplasia complications in Germany: a retrospective cohort study" @default.
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• W4309509750 doi "https://doi.org/10.1080/00325481.2022.2149156" @default.
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