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- W4309510062 abstract "Antibody-drug conjugates (ADCs) are a relatively new class of anti-cancer therapies approved for a number of malignancies, including breast cancer. Their unique structure, consisting of a monoclonal antibody connected via a linker to a toxic payload, combines characteristics of both targeted therapy and chemotherapy.In this review, we discuss the unique molecular structure and pharmacologic principles of ADCs and present the clinical efficacy and relevant toxicities of ADCs both approved and in development. While HER2 is the most studied target with approved agents for both HER2-positive and HER2-low expressing tumors, novel targets in HER2-negative disease have expanded our therapeutic capabilities significantly.ADCs are a promising, novel drug class with significant efficacy in all breast cancer subtypes. They are generally safe and well-tolerated. However, further research is necessary to improve their therapeutic potential. The development of predictive biomarkers to identify patients with greatest benefit, improved understanding of drug resistance to advance combination therapies, and novel targets are needed to further the field." @default.
- W4309510062 created "2022-11-28" @default.
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- W4309510062 date "2022-11-21" @default.
- W4309510062 modified "2023-10-16" @default.
- W4309510062 title "The evolving therapeutic landscape of antibody–drug conjugates in breast cancer" @default.
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- W4309510062 doi "https://doi.org/10.1080/14737140.2022.2147510" @default.
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