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• W4309516228 abstract "Abstract ER, PgR and HER‐2 status are the cornerstones of choosing systemic therapy for breast cancer, but can change during the disease course. Guidelines recommended the biopsy of the metastatic tumor to reassess receptor status. Bone is the most frequent metastatic site of breast cancer but remained technically difficult to biopsy. Our study aimed to evaluate the incidence and prognostic significance of receptor discordance between primary breast cancer and paired bone metastases. One hundred and fifty‐five breast cancer patients were diagnosed with pathology‐confirmed bone metastasis at Fudan University Shanghai Cancer Center. Ninety‐three patients with receptor status available on both primary tumor and bone metastases were included in our study. ER, PgR and HER‐2 status converted from positive to negative in 10.8% (10/93), 28.0% (26/93) and 8.6% (8/93) of the patients, while ER, PgR and HER‐2 status converted from negative to positive in 3.2% (3/93), 4.3% (4/93) and 1.1% (1/93) of the patients, respectively. 40.4% (17/42) of the HER2‐0 tumors converted to HER2‐low, which enabled them to receive the treatment of new antibody‐drug conjugates (ADCs). Prior endocrine and anti‐HER2 therapy were the independent risk factors for receptor conversion. Loss of HR expression in bone metastases was significantly associated with worse first‐line PFS (adjusted hazard ratio = 3.271, P ‐value = .039) and OS (adjusted hazard ratio = 6.09, P ‐value = .011). In conclusion, our study confirmed that patients may experience receptor conversion between primary breast cancer and bone metastases, possibly influenced by prior treatments, which significantly influenced prognosis. The rebiopsy of bone metastases in patients with primary HER2‐0 tumors may benefit from the new ADC drugs." @default.
• W4309516228 created "2022-11-28" @default.
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• W4309516228 date "2022-11-30" @default.
• W4309516228 modified "2023-10-13" @default.
• W4309516228 title "Incidence and prognostic significance of receptor discordance between primary breast cancer and paired bone metastases" @default.
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• W4309516228 doi "https://doi.org/10.1002/ijc.34365" @default.
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