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- W4309516462 abstract "In recent years, the contribution of exosomes to immunity, inflammation and host-pathogen interaction have been appreciated. Exosomes are small secreted extracellular vesicles from endosomal origin that contain a myriad of cellular molecules (protein, nucleic acids), including surface receptors. We have reported a pathogen-induced and macroautophagy/autophagy-dependent class of exosomes coined as “defensosomes”, which protect the host from membrane-targeting toxins. In a recent study, we found that defensosomes decorated with ACE2, the SARS-CoV-2 cellular receptor, are produced in the lungs of patients with COVID-19, and that increased concentration of ACE2-loaded defensosomes is associated with decreased hospitalization length. Mechanistically, SARS-CoV-2 induces the production of ACE2-coated defensosomes, a process requiring the autophagy machinery, which in turn binds and neutralizes the virus. We propose that defensosomes represent a new form of autophagy-mediated innate immunity that contributes to the host’s armamentarium against pathogens." @default.
- W4309516462 created "2022-11-28" @default.
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- W4309516462 date "2022-11-21" @default.
- W4309516462 modified "2023-10-14" @default.
- W4309516462 title "Defensosomes: a new role for autophagy proteins in innate immune defense" @default.
- W4309516462 cites W4295494859 @default.
- W4309516462 doi "https://doi.org/10.1080/15548627.2022.2146894" @default.
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