Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309516703> ?p ?o ?g. }
- W4309516703 abstract "Collagen model peptides (CMPs) consisting of proline-(2S,4R)-hydroxyproline-glycine (POG) repeats have provided a breadth of knowledge of the triple helical structure of collagen, the most abundant protein in mammals. Predictive tools for triple helix stability have, however, lagged behind since the effect of CMPs with different frames ([POG]n , [OGP]n , or [GPO]n ) and capped or uncapped termini have so far been underestimated. Here, we elucidated the impact of the frame, terminal functional group and its charge on the stability of collagen triple helices. Combined experimental and theoretical studies with frame-shifted, capped and uncapped CMPs revealed that electrostatic interactions, strand preorganization, interstrand H-bonding, and steric repulsion at the termini contribute to triple helix stability. We show that these individual contributions are additive and allow for the prediction of the melting temperatures of CMP trimers." @default.
- W4309516703 created "2022-11-28" @default.
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- W4309516703 date "2022-12-14" @default.
- W4309516703 modified "2023-10-11" @default.
- W4309516703 title "Predicting Collagen Triple Helix Stability through Additive Effects of Terminal Residues and Caps" @default.
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- W4309516703 cites W1991706766 @default.
- W4309516703 cites W1995816895 @default.
- W4309516703 cites W2001350716 @default.
- W4309516703 cites W2005746614 @default.
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- W4309516703 cites W2010127700 @default.
- W4309516703 cites W2011669549 @default.
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- W4309516703 cites W2020059634 @default.
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- W4309516703 cites W2026786922 @default.
- W4309516703 cites W2027023682 @default.
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- W4309516703 cites W2050551552 @default.
- W4309516703 cites W2053326095 @default.
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- W4309516703 doi "https://doi.org/10.1002/anie.202214728" @default.
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