Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309518036> ?p ?o ?g. }
- W4309518036 abstract "Mitophagy, a type of selective autophagy, specifically targets damaged mitochondria. The ULK complex regulates Parkin-mediated mitophagy, but the mechanism through which the ULK complex initiates mitophagosome formation remains unknown. The Rab7 GTPase (herein referring to Rab7a) is a key initiator of mitophagosome formation, and Ser-72 phosphorylation of Rab7 is important for this process. We have previously identified LRRK1 as a protein kinase responsible for Rab7 Ser-72 phosphorylation. In this study, we investigated the role of LRRK1 in mitophagy. We showed that LRRK1 functions downstream of ULK1 and ULK2 in Parkin-mediated mitophagy. Furthermore, we demonstrated that ectopic targeting of active LRRK1 to mitochondria is sufficient to induce the Ser-72 phosphorylation of Rab7, circumventing the requirement for ATG13, a component of the ULK complex. Thus, the ULK complex recruits LRRK1 to mitochondria by interacting with ATG13 to initiate mitophagosome formation. This study highlights the crucial role of the ULK complex-LRRK1 axis in the regulation of Parkin-mediated mitophagy." @default.
- W4309518036 created "2022-11-28" @default.
- W4309518036 creator A5001407095 @default.
- W4309518036 creator A5029913526 @default.
- W4309518036 creator A5044169222 @default.
- W4309518036 creator A5044516003 @default.
- W4309518036 creator A5065826771 @default.
- W4309518036 creator A5079762632 @default.
- W4309518036 date "2022-12-01" @default.
- W4309518036 modified "2023-10-02" @default.
- W4309518036 title "The ULK complex–LRRK1 axis regulates Parkin-mediated mitophagy via Rab7 Ser-72 phosphorylation" @default.
- W4309518036 cites W1989109210 @default.
- W4309518036 cites W1994668150 @default.
- W4309518036 cites W2014459126 @default.
- W4309518036 cites W2017828774 @default.
- W4309518036 cites W2034087770 @default.
- W4309518036 cites W2043276141 @default.
- W4309518036 cites W2050849483 @default.
- W4309518036 cites W2052889619 @default.
- W4309518036 cites W2077757969 @default.
- W4309518036 cites W2082425146 @default.
- W4309518036 cites W2086342392 @default.
- W4309518036 cites W2087592289 @default.
- W4309518036 cites W2090879474 @default.
- W4309518036 cites W2103230459 @default.
- W4309518036 cites W2108326484 @default.
- W4309518036 cites W2135450099 @default.
- W4309518036 cites W2137317629 @default.
- W4309518036 cites W2137651420 @default.
- W4309518036 cites W2138311396 @default.
- W4309518036 cites W2140654974 @default.
- W4309518036 cites W2143161560 @default.
- W4309518036 cites W2149200223 @default.
- W4309518036 cites W2150168624 @default.
- W4309518036 cites W2155015733 @default.
- W4309518036 cites W2156356581 @default.
- W4309518036 cites W2167192779 @default.
- W4309518036 cites W2167867141 @default.
- W4309518036 cites W2174370490 @default.
- W4309518036 cites W2253950023 @default.
- W4309518036 cites W2309978978 @default.
- W4309518036 cites W2323582440 @default.
- W4309518036 cites W2511725062 @default.
- W4309518036 cites W2560000662 @default.
- W4309518036 cites W2606589731 @default.
- W4309518036 cites W2768016303 @default.
- W4309518036 cites W2770032330 @default.
- W4309518036 cites W2784886035 @default.
- W4309518036 cites W2788644497 @default.
- W4309518036 cites W2792549532 @default.
- W4309518036 cites W2793220267 @default.
- W4309518036 cites W2887998229 @default.
- W4309518036 cites W2900687171 @default.
- W4309518036 cites W2910996474 @default.
- W4309518036 cites W2922182434 @default.
- W4309518036 cites W2934652181 @default.
- W4309518036 cites W2946762419 @default.
- W4309518036 cites W2980005681 @default.
- W4309518036 cites W3022527720 @default.
- W4309518036 cites W3085949880 @default.
- W4309518036 doi "https://doi.org/10.1242/jcs.260395" @default.
- W4309518036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36408770" @default.
- W4309518036 hasPublicationYear "2022" @default.
- W4309518036 type Work @default.
- W4309518036 citedByCount "3" @default.
- W4309518036 countsByYear W43095180362022 @default.
- W4309518036 countsByYear W43095180362023 @default.
- W4309518036 crossrefType "journal-article" @default.
- W4309518036 hasAuthorship W4309518036A5001407095 @default.
- W4309518036 hasAuthorship W4309518036A5029913526 @default.
- W4309518036 hasAuthorship W4309518036A5044169222 @default.
- W4309518036 hasAuthorship W4309518036A5044516003 @default.
- W4309518036 hasAuthorship W4309518036A5065826771 @default.
- W4309518036 hasAuthorship W4309518036A5079762632 @default.
- W4309518036 hasBestOaLocation W43095180361 @default.
- W4309518036 hasConcept C11960822 @default.
- W4309518036 hasConcept C12554922 @default.
- W4309518036 hasConcept C142724271 @default.
- W4309518036 hasConcept C190283241 @default.
- W4309518036 hasConcept C192562407 @default.
- W4309518036 hasConcept C203522944 @default.
- W4309518036 hasConcept C2776804853 @default.
- W4309518036 hasConcept C2777668072 @default.
- W4309518036 hasConcept C2779134260 @default.
- W4309518036 hasConcept C2779324830 @default.
- W4309518036 hasConcept C2779734285 @default.
- W4309518036 hasConcept C28859421 @default.
- W4309518036 hasConcept C55493867 @default.
- W4309518036 hasConcept C71924100 @default.
- W4309518036 hasConcept C86803240 @default.
- W4309518036 hasConcept C95444343 @default.
- W4309518036 hasConceptScore W4309518036C11960822 @default.
- W4309518036 hasConceptScore W4309518036C12554922 @default.
- W4309518036 hasConceptScore W4309518036C142724271 @default.
- W4309518036 hasConceptScore W4309518036C190283241 @default.
- W4309518036 hasConceptScore W4309518036C192562407 @default.
- W4309518036 hasConceptScore W4309518036C203522944 @default.
- W4309518036 hasConceptScore W4309518036C2776804853 @default.
- W4309518036 hasConceptScore W4309518036C2777668072 @default.
- W4309518036 hasConceptScore W4309518036C2779134260 @default.