FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309521495> ?p ?o ?g. }

• W4309521495 endingPage "448" @default.
• W4309521495 startingPage "438" @default.
• W4309521495 abstract "Hypoxia plays a crucial role in pulmonary vascular remodelling at the early stage of chronic obstructive pulmonary disease (COPD). Circle RNA (circRNA) has been identified to play a critical role in multiple diseases. However, the role of circRNAs in pulmonary vascular remodelling in COPD remains unclear. In this study, we aim to investigate the role of circRNAs in pulmonary arterial smooth muscle cell proliferation and pulmonary vascular remodelling in COPD. COPD patients show lower partial pressure of arterial oxygen and pulmonary arterial remodeling as compared with controls. circRNA microarray and real-time PCR analyses show significantly higher level of circ-BPTF and lower miR-486-5p level in the pulmonary arteries of COPD patients as compared with controls. Hypoxia suppresses miR-486-5p expression but promotes expressions of circ-BPTF and cell migration inducing protein (CEMIP) in human pulmonary arterial smooth muscle cells (PASMCs) in vitro. Loss- and gain-of-function experiments show that circ-BPTF promotes PASMC proliferation in vitro. Moreover, luciferase reporter assay results indicate that circ-BPTF regulates PASMC proliferation by acting as an miR-486-5p sponge. CEMIP is identified as a candidate target gene of miR-486-5p by luciferase reporter assay. Overall, our study shows that circ-BPTF serves as a miR-486-5p sponge to regulate CEMIP and promote hypoxic PASMC proliferation in pulmonary vascular remodelling in COPD." @default.
• W4309521495 created "2022-11-28" @default.
• W4309521495 creator A5003769106 @default.
• W4309521495 creator A5031042628 @default.
• W4309521495 creator A5038784500 @default.
• W4309521495 creator A5069526812 @default.
• W4309521495 creator A5080423822 @default.
• W4309521495 creator A5080890441 @default.
• W4309521495 creator A5080922192 @default.
• W4309521495 date "2022-12-09" @default.
• W4309521495 modified "2023-09-23" @default.
• W4309521495 title "circ-BPTF serves as a miR-486-5p sponge to regulate CEMIP and promotes hypoxic pulmonary arterial smooth muscle cell proliferation in COPD" @default.
• W4309521495 cites W1963515601 @default.
• W4309521495 cites W1986345950 @default.
• W4309521495 cites W2076278145 @default.
• W4309521495 cites W2094589173 @default.
• W4309521495 cites W2135730693 @default.
• W4309521495 cites W2144613920 @default.
• W4309521495 cites W2293880235 @default.
• W4309521495 cites W2311607815 @default.
• W4309521495 cites W2332143265 @default.
• W4309521495 cites W2591947019 @default.
• W4309521495 cites W2760533666 @default.
• W4309521495 cites W2791564799 @default.
• W4309521495 cites W2797804584 @default.
• W4309521495 cites W2904463477 @default.
• W4309521495 cites W2912489217 @default.
• W4309521495 cites W2913939410 @default.
• W4309521495 cites W2921556019 @default.
• W4309521495 cites W2934320411 @default.
• W4309521495 cites W2939760657 @default.
• W4309521495 cites W2965962585 @default.
• W4309521495 cites W2971438293 @default.
• W4309521495 cites W2972600410 @default.
• W4309521495 cites W2987834130 @default.
• W4309521495 cites W2999636577 @default.
• W4309521495 cites W3004712577 @default.
• W4309521495 cites W3006593181 @default.
• W4309521495 cites W3010365107 @default.
• W4309521495 cites W3016897504 @default.
• W4309521495 cites W3018954054 @default.
• W4309521495 cites W3023196218 @default.
• W4309521495 cites W3089277032 @default.
• W4309521495 cites W3090396682 @default.
• W4309521495 cites W3133670499 @default.
• W4309521495 cites W3133707758 @default.
• W4309521495 cites W3196193518 @default.
• W4309521495 doi "https://doi.org/10.3724/abbs.2022178" @default.
• W4309521495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36514216" @default.
• W4309521495 hasPublicationYear "2022" @default.
• W4309521495 type Work @default.
• W4309521495 citedByCount "2" @default.
• W4309521495 countsByYear W43095214952023 @default.
• W4309521495 crossrefType "journal-article" @default.
• W4309521495 hasAuthorship W4309521495A5003769106 @default.
• W4309521495 hasAuthorship W4309521495A5031042628 @default.
• W4309521495 hasAuthorship W4309521495A5038784500 @default.
• W4309521495 hasAuthorship W4309521495A5069526812 @default.
• W4309521495 hasAuthorship W4309521495A5080423822 @default.
• W4309521495 hasAuthorship W4309521495A5080890441 @default.
• W4309521495 hasAuthorship W4309521495A5080922192 @default.
• W4309521495 hasBestOaLocation W43095214952 @default.
• W4309521495 hasConcept C104317684 @default.
• W4309521495 hasConcept C111335760 @default.
• W4309521495 hasConcept C126322002 @default.
• W4309521495 hasConcept C134018914 @default.
• W4309521495 hasConcept C145059251 @default.
• W4309521495 hasConcept C164705383 @default.
• W4309521495 hasConcept C178790620 @default.
• W4309521495 hasConcept C185592680 @default.
• W4309521495 hasConcept C2776780178 @default.
• W4309521495 hasConcept C2779395532 @default.
• W4309521495 hasConcept C2780940725 @default.
• W4309521495 hasConcept C2992686903 @default.
• W4309521495 hasConcept C502942594 @default.
• W4309521495 hasConcept C540031477 @default.
• W4309521495 hasConcept C54009773 @default.
• W4309521495 hasConcept C55493867 @default.
• W4309521495 hasConcept C62112901 @default.
• W4309521495 hasConcept C71924100 @default.
• W4309521495 hasConcept C7836513 @default.
• W4309521495 hasConcept C86803240 @default.
• W4309521495 hasConcept C99322962 @default.
• W4309521495 hasConceptScore W4309521495C104317684 @default.
• W4309521495 hasConceptScore W4309521495C111335760 @default.
• W4309521495 hasConceptScore W4309521495C126322002 @default.
• W4309521495 hasConceptScore W4309521495C134018914 @default.
• W4309521495 hasConceptScore W4309521495C145059251 @default.
• W4309521495 hasConceptScore W4309521495C164705383 @default.
• W4309521495 hasConceptScore W4309521495C178790620 @default.
• W4309521495 hasConceptScore W4309521495C185592680 @default.
• W4309521495 hasConceptScore W4309521495C2776780178 @default.
• W4309521495 hasConceptScore W4309521495C2779395532 @default.
• W4309521495 hasConceptScore W4309521495C2780940725 @default.
• W4309521495 hasConceptScore W4309521495C2992686903 @default.
• W4309521495 hasConceptScore W4309521495C502942594 @default.
• W4309521495 hasConceptScore W4309521495C540031477 @default.
• W4309521495 hasConceptScore W4309521495C54009773 @default.

• next