Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309541595> ?p ?o ?g. }
- W4309541595 endingPage "105651" @default.
- W4309541595 startingPage "105651" @default.
- W4309541595 abstract "The productive infection of HIV, which generates new viral progeny, depends on the activation status of the cell. In this study, we found cocaine exposure sensitizes partially active CD4+ T cells and makes them poised for productive HIV infection. We discovered that cocaine treatment enhances the metabolic state of the cells by co-stimulating several transcription factors, mainly NFAT and AP-1, the two transcription factors, which specifically play a crucial role in enhancing both HIV and the overall cellular gene expression in T cells. We found that cocaine-induced AP-1 works in tandem with NFAT to boost HIV transcription. The enhanced HIV transcription upon cocaine exposure was further confirmed through higher phosphorylation of the crucial serine residues at the carboxyl-terminal domain (CTD) of RNA polymerase II. The insights gained from this study could aid in developing highly specialized therapeutics combating the deleterious effects of cocaine on the cocaine-using HIV population." @default.
- W4309541595 created "2022-11-28" @default.
- W4309541595 creator A5048051126 @default.
- W4309541595 creator A5057491718 @default.
- W4309541595 creator A5070195491 @default.
- W4309541595 creator A5089804823 @default.
- W4309541595 date "2022-12-01" @default.
- W4309541595 modified "2023-10-12" @default.
- W4309541595 title "Cocaine sensitizes the CD4+ T cells for HIV infection by co-stimulating NFAT and AP-1" @default.
- W4309541595 cites W1503471785 @default.
- W4309541595 cites W1536272460 @default.
- W4309541595 cites W1566451994 @default.
- W4309541595 cites W1607881510 @default.
- W4309541595 cites W1847275787 @default.
- W4309541595 cites W1968449615 @default.
- W4309541595 cites W1979678532 @default.
- W4309541595 cites W1991210089 @default.
- W4309541595 cites W2001592123 @default.
- W4309541595 cites W2005312953 @default.
- W4309541595 cites W2007801675 @default.
- W4309541595 cites W2012261742 @default.
- W4309541595 cites W2013408244 @default.
- W4309541595 cites W2014981455 @default.
- W4309541595 cites W2024754980 @default.
- W4309541595 cites W2026181894 @default.
- W4309541595 cites W2034185625 @default.
- W4309541595 cites W2035142627 @default.
- W4309541595 cites W2036145275 @default.
- W4309541595 cites W2060323540 @default.
- W4309541595 cites W2062939266 @default.
- W4309541595 cites W2068993874 @default.
- W4309541595 cites W2073580835 @default.
- W4309541595 cites W2074475161 @default.
- W4309541595 cites W2081550460 @default.
- W4309541595 cites W2089307417 @default.
- W4309541595 cites W2102824612 @default.
- W4309541595 cites W2120805822 @default.
- W4309541595 cites W2121283431 @default.
- W4309541595 cites W2122083453 @default.
- W4309541595 cites W2136683144 @default.
- W4309541595 cites W2137551688 @default.
- W4309541595 cites W2140707292 @default.
- W4309541595 cites W2148379368 @default.
- W4309541595 cites W2151217565 @default.
- W4309541595 cites W2153090354 @default.
- W4309541595 cites W2154853638 @default.
- W4309541595 cites W2157973267 @default.
- W4309541595 cites W2164660469 @default.
- W4309541595 cites W219872739 @default.
- W4309541595 cites W2202782308 @default.
- W4309541595 cites W2211002846 @default.
- W4309541595 cites W2252861946 @default.
- W4309541595 cites W2264544376 @default.
- W4309541595 cites W2309617203 @default.
- W4309541595 cites W2315560217 @default.
- W4309541595 cites W2327006078 @default.
- W4309541595 cites W2591978212 @default.
- W4309541595 cites W2592935721 @default.
- W4309541595 cites W2610867895 @default.
- W4309541595 cites W2791358733 @default.
- W4309541595 cites W2897440762 @default.
- W4309541595 cites W2918637626 @default.
- W4309541595 cites W2971401301 @default.
- W4309541595 cites W2998394393 @default.
- W4309541595 cites W3008921452 @default.
- W4309541595 cites W3022823009 @default.
- W4309541595 cites W3030802701 @default.
- W4309541595 cites W3047664661 @default.
- W4309541595 cites W3087534864 @default.
- W4309541595 cites W3091955100 @default.
- W4309541595 cites W3120282064 @default.
- W4309541595 cites W3186493307 @default.
- W4309541595 cites W3208054771 @default.
- W4309541595 cites W4214652814 @default.
- W4309541595 cites W4281807111 @default.
- W4309541595 cites W58595177 @default.
- W4309541595 doi "https://doi.org/10.1016/j.isci.2022.105651" @default.
- W4309541595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36483012" @default.
- W4309541595 hasPublicationYear "2022" @default.
- W4309541595 type Work @default.
- W4309541595 citedByCount "2" @default.
- W4309541595 countsByYear W43095415952023 @default.
- W4309541595 crossrefType "journal-article" @default.
- W4309541595 hasAuthorship W4309541595A5048051126 @default.
- W4309541595 hasAuthorship W4309541595A5057491718 @default.
- W4309541595 hasAuthorship W4309541595A5070195491 @default.
- W4309541595 hasAuthorship W4309541595A5089804823 @default.
- W4309541595 hasBestOaLocation W43095415951 @default.
- W4309541595 hasConcept C101762097 @default.
- W4309541595 hasConcept C104317684 @default.
- W4309541595 hasConcept C138885662 @default.
- W4309541595 hasConcept C150194340 @default.
- W4309541595 hasConcept C179926584 @default.
- W4309541595 hasConcept C185592680 @default.
- W4309541595 hasConcept C189938988 @default.
- W4309541595 hasConcept C203014093 @default.
- W4309541595 hasConcept C2776090121 @default.
- W4309541595 hasConcept C2908647359 @default.