Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309551142> ?p ?o ?g. }
- W4309551142 endingPage "199010" @default.
- W4309551142 startingPage "199010" @default.
- W4309551142 abstract "Comorbidities such as diabetes worsen COVID-19 severity and recovery. Metformin, a first-line medication for type 2 diabetes, has antiviral properties and certain studies have also indicated its prognostic potential in COVID-19. Here, we report that metformin significantly inhibits SARS-CoV-2 growth in cell culture models. First, a steady increase in AMPK phosphorylation was detected as infection progressed, suggesting its important role during viral infection. Activation of AMPK in Calu3 and Caco2 cell lines using metformin revealed that metformin suppresses SARS-CoV-2 infectious titers up to 99%, in both naïve as well as infected cells. IC50 values from dose-variation studies in infected cells were found to be 0.4 and 1.43 mM in Calu3 and Caco2 cells, respectively. Role of AMPK in metformin's antiviral suppression was further confirmed using other pharmacological compounds, AICAR and Compound C. Collectively, our study demonstrates that metformin is effective in limiting the replication of SARS-CoV-2 in cell culture and thus possibly could offer double benefits as diabetic COVID-19 patients by lowering both blood glucose levels and viral load." @default.
- W4309551142 created "2022-11-28" @default.
- W4309551142 creator A5007716354 @default.
- W4309551142 creator A5073575308 @default.
- W4309551142 creator A5076939609 @default.
- W4309551142 creator A5078075660 @default.
- W4309551142 date "2023-01-01" @default.
- W4309551142 modified "2023-10-17" @default.
- W4309551142 title "Metformin suppresses SARS-CoV-2 in cell culture" @default.
- W4309551142 cites W1968062717 @default.
- W4309551142 cites W1990768419 @default.
- W4309551142 cites W2023422813 @default.
- W4309551142 cites W2026413615 @default.
- W4309551142 cites W2026861492 @default.
- W4309551142 cites W2030900785 @default.
- W4309551142 cites W2033578503 @default.
- W4309551142 cites W2035964160 @default.
- W4309551142 cites W2052757428 @default.
- W4309551142 cites W2057967679 @default.
- W4309551142 cites W2068845408 @default.
- W4309551142 cites W2086825927 @default.
- W4309551142 cites W2099540110 @default.
- W4309551142 cites W2118222538 @default.
- W4309551142 cites W2133293695 @default.
- W4309551142 cites W2134907909 @default.
- W4309551142 cites W2138226825 @default.
- W4309551142 cites W2143824349 @default.
- W4309551142 cites W2148755064 @default.
- W4309551142 cites W2152407075 @default.
- W4309551142 cites W2288428124 @default.
- W4309551142 cites W2317113145 @default.
- W4309551142 cites W2547657405 @default.
- W4309551142 cites W2576839195 @default.
- W4309551142 cites W2740986674 @default.
- W4309551142 cites W2743010525 @default.
- W4309551142 cites W2763871199 @default.
- W4309551142 cites W2766172571 @default.
- W4309551142 cites W2781893963 @default.
- W4309551142 cites W2791346573 @default.
- W4309551142 cites W2904824676 @default.
- W4309551142 cites W2945488840 @default.
- W4309551142 cites W3001118548 @default.
- W4309551142 cites W3009912996 @default.
- W4309551142 cites W3014751348 @default.
- W4309551142 cites W3016829967 @default.
- W4309551142 cites W3020909574 @default.
- W4309551142 cites W3021684016 @default.
- W4309551142 cites W3026002191 @default.
- W4309551142 cites W3027187955 @default.
- W4309551142 cites W3038063455 @default.
- W4309551142 cites W3072304586 @default.
- W4309551142 cites W3092637289 @default.
- W4309551142 cites W3108321961 @default.
- W4309551142 cites W3109186718 @default.
- W4309551142 cites W3110332236 @default.
- W4309551142 cites W3111603242 @default.
- W4309551142 cites W3112693555 @default.
- W4309551142 cites W3119033482 @default.
- W4309551142 cites W3134567456 @default.
- W4309551142 cites W3135963844 @default.
- W4309551142 cites W3143604394 @default.
- W4309551142 cites W3155805951 @default.
- W4309551142 cites W3157337586 @default.
- W4309551142 cites W3162715156 @default.
- W4309551142 cites W3177256923 @default.
- W4309551142 cites W3183437698 @default.
- W4309551142 cites W3184339862 @default.
- W4309551142 cites W3197082153 @default.
- W4309551142 cites W3203180701 @default.
- W4309551142 cites W4224054156 @default.
- W4309551142 cites W4283025473 @default.
- W4309551142 doi "https://doi.org/10.1016/j.virusres.2022.199010" @default.
- W4309551142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36417940" @default.
- W4309551142 hasPublicationYear "2023" @default.
- W4309551142 type Work @default.
- W4309551142 citedByCount "12" @default.
- W4309551142 countsByYear W43095511422023 @default.
- W4309551142 crossrefType "journal-article" @default.
- W4309551142 hasAuthorship W4309551142A5007716354 @default.
- W4309551142 hasAuthorship W4309551142A5073575308 @default.
- W4309551142 hasAuthorship W4309551142A5076939609 @default.
- W4309551142 hasAuthorship W4309551142A5078075660 @default.
- W4309551142 hasBestOaLocation W43095511421 @default.
- W4309551142 hasConcept C11960822 @default.
- W4309551142 hasConcept C126322002 @default.
- W4309551142 hasConcept C134018914 @default.
- W4309551142 hasConcept C1491633281 @default.
- W4309551142 hasConcept C159047783 @default.
- W4309551142 hasConcept C203014093 @default.
- W4309551142 hasConcept C2777180221 @default.
- W4309551142 hasConcept C2777752497 @default.
- W4309551142 hasConcept C2779134260 @default.
- W4309551142 hasConcept C2780124434 @default.
- W4309551142 hasConcept C2780323712 @default.
- W4309551142 hasConcept C3008058167 @default.
- W4309551142 hasConcept C524204448 @default.
- W4309551142 hasConcept C54355233 @default.
- W4309551142 hasConcept C55493867 @default.