Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309551302> ?p ?o ?g. }
- W4309551302 endingPage "101148" @default.
- W4309551302 startingPage "101148" @default.
- W4309551302 abstract "Corneal and conjunctival epithelia arise from a common ancestral ectoderm cell, then diverge into distinct lineages. The former develops into a multilayered stratified squamous epithelium, the latter into an expansive mucous membrane that stretches the eyelid margin to the cornea's outskirts. The limbus, which intersects these epithelia, is purported to harbor corneal stem cells. Intrinsic programs that prevent these neighbouring epithelia from mixing and changing identity have not been elucidated, however microenvironmental cues that emanate following tissue damage and ensuing disease, dictate cell fate choices including those that influence form and function. Plasticity of ocular surface epithelia is gauged by their ability to undergo epithelial-mesenchymal transition, transdifferentiation, dedifferentiation and metaplastic transformation. Elucidating the molecular mechanism by which these rare and unusual phenomena arise, and persuading cells to either revert to their original state or remain newly committed, could be exploited into game-changing therapeutics for patients with corneal blindness and other diseases." @default.
- W4309551302 created "2022-11-28" @default.
- W4309551302 creator A5034321862 @default.
- W4309551302 creator A5079394170 @default.
- W4309551302 date "2023-07-01" @default.
- W4309551302 modified "2023-10-14" @default.
- W4309551302 title "Cell identity changes in ocular surface Epithelia" @default.
- W4309551302 cites W1566556117 @default.
- W4309551302 cites W1593141554 @default.
- W4309551302 cites W1857061736 @default.
- W4309551302 cites W1954007937 @default.
- W4309551302 cites W1964761197 @default.
- W4309551302 cites W1965182610 @default.
- W4309551302 cites W1965686131 @default.
- W4309551302 cites W1965836798 @default.
- W4309551302 cites W1968106422 @default.
- W4309551302 cites W1968231752 @default.
- W4309551302 cites W1968663547 @default.
- W4309551302 cites W1969383593 @default.
- W4309551302 cites W1970246267 @default.
- W4309551302 cites W1970969524 @default.
- W4309551302 cites W1973034778 @default.
- W4309551302 cites W1973281247 @default.
- W4309551302 cites W1976416430 @default.
- W4309551302 cites W1976882526 @default.
- W4309551302 cites W1977042614 @default.
- W4309551302 cites W1977091888 @default.
- W4309551302 cites W1978045632 @default.
- W4309551302 cites W1978582812 @default.
- W4309551302 cites W1978818002 @default.
- W4309551302 cites W1980254549 @default.
- W4309551302 cites W1980676641 @default.
- W4309551302 cites W1981193134 @default.
- W4309551302 cites W1981360283 @default.
- W4309551302 cites W1982220589 @default.
- W4309551302 cites W1982347881 @default.
- W4309551302 cites W1982703499 @default.
- W4309551302 cites W1984309285 @default.
- W4309551302 cites W1985175887 @default.
- W4309551302 cites W1987475753 @default.
- W4309551302 cites W1987690014 @default.
- W4309551302 cites W1987932243 @default.
- W4309551302 cites W1988368673 @default.
- W4309551302 cites W1989165783 @default.
- W4309551302 cites W1989473589 @default.
- W4309551302 cites W1989533997 @default.
- W4309551302 cites W1989706815 @default.
- W4309551302 cites W1989940296 @default.
- W4309551302 cites W1992585607 @default.
- W4309551302 cites W1993739774 @default.
- W4309551302 cites W1995717532 @default.
- W4309551302 cites W1995865777 @default.
- W4309551302 cites W1996421122 @default.
- W4309551302 cites W1997428070 @default.
- W4309551302 cites W2000193598 @default.
- W4309551302 cites W2002596047 @default.
- W4309551302 cites W2004391026 @default.
- W4309551302 cites W2004972310 @default.
- W4309551302 cites W2005027059 @default.
- W4309551302 cites W2014421736 @default.
- W4309551302 cites W2014498510 @default.
- W4309551302 cites W2014888598 @default.
- W4309551302 cites W2016768725 @default.
- W4309551302 cites W2018073132 @default.
- W4309551302 cites W2022084143 @default.
- W4309551302 cites W2026314752 @default.
- W4309551302 cites W2026735571 @default.
- W4309551302 cites W2027161722 @default.
- W4309551302 cites W2027700219 @default.
- W4309551302 cites W2030330654 @default.
- W4309551302 cites W2031414670 @default.
- W4309551302 cites W2033690523 @default.
- W4309551302 cites W2039751095 @default.
- W4309551302 cites W2040249596 @default.
- W4309551302 cites W2041738284 @default.
- W4309551302 cites W2042391170 @default.
- W4309551302 cites W2043541388 @default.
- W4309551302 cites W2044405591 @default.
- W4309551302 cites W2047663647 @default.
- W4309551302 cites W2048031522 @default.
- W4309551302 cites W2049190316 @default.
- W4309551302 cites W2049207532 @default.
- W4309551302 cites W2050107691 @default.
- W4309551302 cites W2051048131 @default.
- W4309551302 cites W2052354463 @default.
- W4309551302 cites W2054669405 @default.
- W4309551302 cites W2054915695 @default.
- W4309551302 cites W2055976270 @default.
- W4309551302 cites W2056350000 @default.
- W4309551302 cites W2059080995 @default.
- W4309551302 cites W2059653912 @default.
- W4309551302 cites W2061584984 @default.
- W4309551302 cites W2062187866 @default.
- W4309551302 cites W2063326250 @default.
- W4309551302 cites W2065437825 @default.
- W4309551302 cites W2067134465 @default.
- W4309551302 cites W2067228972 @default.
- W4309551302 cites W2067733585 @default.