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- W4309552440 endingPage "100091" @default.
- W4309552440 startingPage "100091" @default.
- W4309552440 abstract "PurposeThe purpose of this critical review is to summarize and evaluate the existing serum biomarkers currently proposed for the identification and evaluation of osteoarthritis onset and progression in three populations: healthy-, anterior cruciate ligament reconstructed- and osteoarthritic knees using the BIPED classification.MethodsArticles that reported on serum biomarkers in individuals with healthy, anterior cruciate ligament reconstructed and osteoarthritic knees were collected from peer-reviewed sources available on Medline (2000 through March 2020). Search terms included the following: serum AND biomarker AND knee AND osteoarthritis AND healthy AND (“anterior cruciate ligament” OR “anterior cruciate ligament reconstruction” OR “ACLR”). Articles were limited to studies in humans, written in English and full text accessible. All serum biomarkers evaluated in the gathered manuscripts were classified according to the BIPED classification.ResultsA total of 164 unique serum biomarkers were identified across healthy individuals, 18 reported on patients after knee injury (commonly ACLR), 71 reported on patients with diagnosed OA and 5 reported mixed populations. Biomarkers studied most frequently include serum COMP, interleukin-6, C2C, CPII, hyaluronic acid, tumor necrosis factor- alpha, c-reactive protein, MMP-3, high sensitivity-CRP, IL-8 and IL-1B, CS846, YKL-40, and C1,2C.DiscussionThe results highlight large variations in how these biomarkers respond to different stimuli across multiple populations. The most frequently studied biomarkers were those categorized under the BIPEDs criteria as diagnostic, burden of disease and prognostic biomarkers. More robust and longitudinal research on serum biomarkers needs to be conducted in these 3 populations." @default.
- W4309552440 created "2022-11-28" @default.
- W4309552440 creator A5018971052 @default.
- W4309552440 creator A5035909262 @default.
- W4309552440 creator A5039981966 @default.
- W4309552440 date "2023-06-01" @default.
- W4309552440 modified "2023-10-17" @default.
- W4309552440 title "Serum biomarkers in healthy, injured, and osteoarthritic knees: a critical review" @default.
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