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- W4309553629 endingPage "114023" @default.
- W4309553629 startingPage "114023" @default.
- W4309553629 abstract "N6-methyladenosine (m6A) modification is the most abundant post-transcriptional regulation of RNAs in eukaryotes. Dysregulation of m6A readers, writers, and erasers can significantly promote tumorigenesis by altering the expression of various genes. Wnt/β-catenin is an evolutionarily conserved signaling pathway that has recently been linked to the pathogenesis of many cancers. Given the significance of this pathway in regulating normal tissue homeostasis and stem cell differentiation, a subtle understanding of the molecular mechanism underlying its dysregulation is required for effective targeting. There is mounting evidence that m6A regulators are highly implicated in the dysregulation of the Wnt/β-catenin signaling pathway. Since m6A regulators can affect Wnt pathway components and dysregulation of either leads to carcinogenesis, this study aims to clarify the relationship between m6A regulators and the Wnt/β-catenin signaling pathway to investigate their combined impact on tumorigenesis." @default.
- W4309553629 created "2022-11-28" @default.
- W4309553629 creator A5016155236 @default.
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- W4309553629 creator A5075270242 @default.
- W4309553629 creator A5076972559 @default.
- W4309553629 creator A5091098995 @default.
- W4309553629 date "2023-01-01" @default.
- W4309553629 modified "2023-10-15" @default.
- W4309553629 title "Role of m6A modification in dysregulation of Wnt/β-catenin pathway in cancer" @default.
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- W4309553629 doi "https://doi.org/10.1016/j.biopha.2022.114023" @default.
- W4309553629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36403567" @default.
- W4309553629 hasPublicationYear "2023" @default.
- W4309553629 type Work @default.