Matches in SemOpenAlex for { <https://semopenalex.org/work/W4309556362> ?p ?o ?g. }
- W4309556362 abstract "Bacteria have the potential to translocate between sites in the human body, but the dynamics and consequences of within-host bacterial migration remain poorly understood. Here we investigate the link between gut and lung Pseudomonas aeruginosa populations in an intensively sampled ICU patient using a combination of genomics, isolate phenotyping, host immunity profiling, and clinical data. Crucially, we show that lung colonization in the ICU was driven by the translocation of P. aeruginosa from the gut. Meropenem treatment for a suspected urinary tract infection selected for elevated resistance in both the gut and lung. However, resistance was driven by parallel evolution in the gut and lung coupled with organ specific selective pressures, and translocation had only a minor impact on AMR. These findings suggest that reducing intestinal colonization of Pseudomonas may be an effective way to prevent lung infections in critically ill patients." @default.
- W4309556362 created "2022-11-28" @default.
- W4309556362 creator A5002038535 @default.
- W4309556362 creator A5022379264 @default.
- W4309556362 creator A5023141945 @default.
- W4309556362 creator A5025395740 @default.
- W4309556362 creator A5036202060 @default.
- W4309556362 creator A5044978106 @default.
- W4309556362 creator A5045034798 @default.
- W4309556362 creator A5048017496 @default.
- W4309556362 creator A5058209322 @default.
- W4309556362 creator A5062836031 @default.
- W4309556362 creator A5071734378 @default.
- W4309556362 creator A5081967303 @default.
- W4309556362 creator A5084625600 @default.
- W4309556362 creator A5085336116 @default.
- W4309556362 creator A5085805590 @default.
- W4309556362 creator A5090085674 @default.
- W4309556362 date "2022-11-22" @default.
- W4309556362 modified "2023-10-17" @default.
- W4309556362 title "Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient" @default.
- W4309556362 cites W1572362092 @default.
- W4309556362 cites W1709269893 @default.
- W4309556362 cites W1802199068 @default.
- W4309556362 cites W1835525578 @default.
- W4309556362 cites W1904922831 @default.
- W4309556362 cites W1926501520 @default.
- W4309556362 cites W1964052073 @default.
- W4309556362 cites W1970785004 @default.
- W4309556362 cites W1982855075 @default.
- W4309556362 cites W1984693521 @default.
- W4309556362 cites W1991924305 @default.
- W4309556362 cites W1995606284 @default.
- W4309556362 cites W2002773042 @default.
- W4309556362 cites W2015502647 @default.
- W4309556362 cites W2026335574 @default.
- W4309556362 cites W2042148090 @default.
- W4309556362 cites W2044584162 @default.
- W4309556362 cites W2044913918 @default.
- W4309556362 cites W2048331099 @default.
- W4309556362 cites W2052280627 @default.
- W4309556362 cites W2058938769 @default.
- W4309556362 cites W2065088137 @default.
- W4309556362 cites W2073556554 @default.
- W4309556362 cites W2076110457 @default.
- W4309556362 cites W2090716796 @default.
- W4309556362 cites W2091326259 @default.
- W4309556362 cites W2096093282 @default.
- W4309556362 cites W2099826413 @default.
- W4309556362 cites W2103441770 @default.
- W4309556362 cites W2107066107 @default.
- W4309556362 cites W2108234281 @default.
- W4309556362 cites W2109618014 @default.
- W4309556362 cites W2119180969 @default.
- W4309556362 cites W2119404698 @default.
- W4309556362 cites W2120902911 @default.
- W4309556362 cites W2123677996 @default.
- W4309556362 cites W2127001823 @default.
- W4309556362 cites W2131271579 @default.
- W4309556362 cites W2142909154 @default.
- W4309556362 cites W2148054572 @default.
- W4309556362 cites W2157721156 @default.
- W4309556362 cites W2169113636 @default.
- W4309556362 cites W2170551349 @default.
- W4309556362 cites W2173144055 @default.
- W4309556362 cites W2273624252 @default.
- W4309556362 cites W2290768068 @default.
- W4309556362 cites W2294528210 @default.
- W4309556362 cites W2323555810 @default.
- W4309556362 cites W2496661162 @default.
- W4309556362 cites W2513727910 @default.
- W4309556362 cites W2527885929 @default.
- W4309556362 cites W2533688570 @default.
- W4309556362 cites W2579114576 @default.
- W4309556362 cites W2615098984 @default.
- W4309556362 cites W2752941584 @default.
- W4309556362 cites W2760331376 @default.
- W4309556362 cites W2768397796 @default.
- W4309556362 cites W2779599349 @default.
- W4309556362 cites W2804230504 @default.
- W4309556362 cites W2891078715 @default.
- W4309556362 cites W2896346062 @default.
- W4309556362 cites W2903863306 @default.
- W4309556362 cites W2947931657 @default.
- W4309556362 cites W2951421477 @default.
- W4309556362 cites W2952167528 @default.
- W4309556362 cites W2964301449 @default.
- W4309556362 cites W2970103499 @default.
- W4309556362 cites W3001883374 @default.
- W4309556362 cites W3043408355 @default.
- W4309556362 cites W3159421822 @default.
- W4309556362 cites W4220841996 @default.
- W4309556362 doi "https://doi.org/10.1038/s41467-022-34101-2" @default.
- W4309556362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36414617" @default.
- W4309556362 hasPublicationYear "2022" @default.
- W4309556362 type Work @default.
- W4309556362 citedByCount "16" @default.
- W4309556362 countsByYear W43095563622023 @default.
- W4309556362 crossrefType "journal-article" @default.
- W4309556362 hasAuthorship W4309556362A5002038535 @default.