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• W4309564543 abstract "Abstract Growing evidence suggests altered oral and gut microbiota in autism spectrum disorder (ASD), but little is known about the alterations and roles of phages, especially within the oral microbiota in ASD subjects. We enrolled ASD ( n = 26) and neurotypical subjects ( n = 26) with their oral hygiene controlled, and the metagenomes of both oral and fecal samples ( n = 104) are shotgun-sequenced and compared. We observe extensive and diverse oral phageome comparable to that of the gut, and clear signals of mouth-to-gut phage strain transfer within individuals. However, the overall phageomes of the two sites are widely different and show even less similarity in the oral communities between ASD and control subjects. The ASD oral phageome exhibits significantly reduced abundance and alpha diversity, but the Streptococcal phages there are atypically enriched, often dominating the community. The over-representation of Streptococcal phages is accompanied by enriched oral Streptococcal virulence factors and Streptococcus bacteria, all exhibiting a positive correlation with the severity of ASD clinical manifestations. These changes are not observed in the parallel sampling of the gut flora, suggesting a previously unknown oral-specific association between the excessive Streptococcal phage enrichment and ASD pathogenesis. The findings provide new evidence for the independent microbiome-mouth-brain connection, deepen our understanding of how the growth dynamics of bacteriophages and oral microbiota contribute to ASD, and point to novel effective therapeutics." @default.
• W4309564543 created "2022-11-28" @default.
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• W4309564543 date "2022-11-18" @default.
• W4309564543 modified "2023-10-18" @default.
• W4309564543 title "Implications of oral streptococcal bacteriophages in autism spectrum disorder" @default.
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• W4309564543 doi "https://doi.org/10.1038/s41522-022-00355-3" @default.
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