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- W4309570695 endingPage "2551" @default.
- W4309570695 startingPage "2551" @default.
- W4309570695 abstract "Chloroquine (CQ) and Hydroxychloroquine (HCQ), initially utilized in the treatment of malaria, have now developed a long list of applications. Despite their clinical relevance, their mechanisms of action are not clearly defined. Major pathways by which these agents are proposed to function include alkalinization of lysosomes and endosomes, downregulation of C-X-C chemokine receptor type 4 (CXCR4) expression, high-mobility group box 1 protein (HMGB1) inhibition, alteration of intracellular calcium, and prevention of thrombus formation. However, there is conflicting data present in the literature. This is likely the result of the complex overlapping pathways between these mechanisms of action that have not previously been highlighted. In fact, prior research has focused on very specific portions of particular pathways without describing these in the context of the extensive CQ/HCQ literature. This review summarizes the detailed data regarding CQ/HCQ's mechanisms of action while also providing insight into the overarching themes. Furthermore, this review provides clinical context to the application of these diverse drugs including their role in malaria, autoimmune disorders, cardiovascular disease, thrombus formation, malignancies, and viral infections." @default.
- W4309570695 created "2022-11-28" @default.
- W4309570695 creator A5015514912 @default.
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- W4309570695 creator A5031362972 @default.
- W4309570695 creator A5040926175 @default.
- W4309570695 creator A5084542798 @default.
- W4309570695 date "2022-11-22" @default.
- W4309570695 modified "2023-09-26" @default.
- W4309570695 title "Biologic Functions of Hydroxychloroquine in Disease: From COVID-19 to Cancer" @default.
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