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• W4309570905 abstract "Aging is a process of progressive deterioration of multiple physiological functions within an organism. This study investigated the anti-aging effects of polysaccharides extracted from ginsenoside residues (GRP) in Caenorhabditis elegans using physiological, microbiomic, and transcriptomic approaches. GRP treatment prolonged the mean lifespan of C. elegans by 58.60 % (19.64 days) and did not affect locomotive behaviors. It reduced levels of lipofuscin and reactive oxygen species (ROS), and increased superoxide dismutase activity, which prevented oxidative damage caused by aging. Microbiomic data indicated that GRP administration significantly altered the composition of gut flora and increased the abundance of beneficial bacteria. Transcriptomic analyses identified 201 differentially expressed genes (DEGs). GRP treatment may enhance fatty acid degradation and induce preferential synthesis of beneficial fatty acids. It may also activate the metabolism of certain amino acids. The transcriptomic data were reliably reproduced using seven vital DEGs, which were confirmed by qRT-PCR analysis. These findings show that GRP has positive effects that prolong lifespan and alleviate aging in C. elegans. GRP should be explored as an effective dietary supplement for the development of functional foods. We propose a potentially novel mechanism that more fully describes the anti-aging mechanisms induced by GRP." @default.
• W4309570905 created "2022-11-28" @default.
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• W4309570905 date "2023-01-01" @default.
• W4309570905 modified "2023-10-06" @default.
• W4309570905 title "Anti-aging effects of polysaccharides from ginseng extract residues in Caenorhabditis elegans" @default.
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• W4309570905 doi "https://doi.org/10.1016/j.ijbiomac.2022.11.168" @default.
• W4309570905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36414078" @default.
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